Candidiasis Treatment Singapore | Shim Clinic

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Candidiasis Treatment is usually with:



Treatment is indicated for symptomatic patients. It is not recommended for asymptomatic patients with a positive Gram stain or culture because 10-20% of women harbour Candida species or other yeasts in the vagina in the absence of symptoms.

General advice

Vulval emollients and or topical antifungal/steroid creams may provide symptomatic relief for secondary associated vulval dermatitis. Avoid local irritants (e.g. perfumed products) and tight fitting clothing (IV, C).

Recommended Regimens

Uncomplicated vulvovaginal candidiasis (VVC)

1. Clotrimazole vaginal pessary 200mg daily x 3 days or 500 mg single dose [II, A]
2. Miconazole nitrate vaginal pessary 200mg daily x 3 days [II, A]
3. Econazole nitrate pessary 150mg intravaginally nightly x 3 days [II, A]
4. Nystatin pessary 100,000 U daily x 7 to 14 days [II, A]
5. Butoconazole 2% cream 5g intravaginally x 1 day [II, A]
6. Fluconazole 150mg orally single dose [II, A]

Alternative Regimens

1. Clotrimazole pessary 100mg or cream (1%) 5g intravaginally daily x 7 days [II, A]
2. Miconazole nitrate vaginal pessary 100mg or cream (2%) 5g intravaginally daily x 7 days [II, A]
3. Tioconazole ointment (6.5%) intravaginally 4.6g in a single application [II, A]
4. Miconazole 1,200mg vaginal pessary x 1 day [II, A]

Note: The topically applied azole drugs are more effective than nystatin.

Candidiasis in pregnancy

Only topical azole therapy should be given. Longer courses may be necessary. Oral azole therapy is contraindicated [II, B].

Candidiasis in HIV infection

Candidiasis tends to occur with a higher frequency and persistence in HIV-positive women and colonization rates correlate with the severity of immunosuppression. These patients should be treated with the same treatment regimens as for HIV-negative women.

Recurrent vulvovaginal candidiasis

This is defined as 4 or more episodes of symptomatic vulvovaginal candidiasis annually. Patients must be evaluated for any predisposing factors e.g. uncontrolled diabetes mellitus, immunosuppression, corticosteroid and long-term antibiotic use. Repeated courses of treatment may be required. Infection by less susceptible yeasts e.g. C glabrata may require a longer duration of therapy.

Systemic treatment may be indicated for resistant/recurrent candidiasis:

Induction Regimens

1. Itraconazole 100mg orally bid x 1-3 days [II, A]
2. Fluconazole 150mg orally single dose [II, A]

Maintenance Regimens

1. Fluconazole 100-200mg orally once a week x 6 months [II, B]
2. Clotrimazole pessary 500mg once a week x 6 months [II, B]
3. Itraconazole 400mg once a month x 6 months [II, B]

Caution: Anecdotal reports of oral contraceptive failure with prolonged oral azole therapy. The creams and suppositories are oil-based and may weaken latex condoms and diaphragms. Risk of idiosyncratic drug-induced hepatitis with itraconazole.




Candidiasis treatment:

Sexual risk (of HIV/STD/pregnancy), and what you can do before and after exposure.
Timeline HIV STD Pregnancy
Before exposure
Abstain from sex, Be faithful, or Condom use
Circumcision (males only)
Contraception (females only)
HIV PrEP (pre-exposure prophylaxis) - Stop HIV infection before exposure STD vaccine: - Hepatitis vaccine - HPV vaccine
STD / HIV exposure
Unsafe sex / unprotected sex: No condom / Condom broke / Condom slip
0-72 hours HIV PEP (post-exposure prophylaxis) - Stop HIV infection after exposure STD testing * - Screening test - to look for asymptomatic infections - from previous exposures Emergency contraception with the morning-after pill (females only)
2 weeks HIV DNA Test
1 month HIV 4th Generation Test - SD Bioline HIV Ag/Ab Combo - Fingerprick blood sampling. - 20 minutes to results
3 months HIV 3rd Generation Test - OraQuick® HIV-1/2 Antibody - Oral fluid or - Fingerprick blood sampling. - 20 minutes to results STD testing * - Full & comprehensive - diagnostic test - to look for current infections
Watch for HIV Symptoms STD Symptoms
If infected HIV Treatment STD Treatment Abortion
* Males: Do not urinate for at least 4 hours before arriving. * Females: testing is more accurate when you are not menstruating.


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