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Human Immunodeficiency Virus (HIV) Treatment, Singapore - Shim Clinic

Human immunodeficiency virus (HIV) is treated with a combination of medications taken daily, to suppress the virus from multiplying, called antiretroviral therapy (ART). ART cannot cure HIV, but allows people living with HIV (PLWH) to live longer and healthier.

There are 3 types of HIV treatment:

Classes of HIV medication:

Entry inhibitors Tradename Dose Freq. FDA Approval
CCR5 inhibitor
maraviroc (MVC) Selzentry 600mg bd 2007 Aug
Fusion inhibitor
enfuvirtide (T-20) Fuzeon 90mg bd 2003 Mar

 

 

  Trade name Dose Freq. FDA App.
NRTI / pyrimidine / thymidine
azidothymidine (AZT) / zidovudine (ZDV) Retrovir 300mg bd 1987 Mar 300mg 250mg
stavudine (d4T) Zerit 40mg bd 1994 Jun 30mg / 40mg
NRTI / pyrimidine / cytidine
lamivudine (3TC) Epivir 300mg od 1995 Nov 150mg 300mg 150mg 150mg
emtricitabine (FTC) Emtriva 200mg od 2003 Jul 200mg 200mg 200mg 200mg 200mg
NRTI / purine / adenosine
didanosine (ddI) Videx 400mg od 1991 Oct
tenofovir disoproxil (TDF) Viread 300mg od 2001 Oct 300mg 300mg 300mg
tenofovir alafenamide (TAF) 10mg 25mg
NRTI / purine / guanosine
abacavir (ABC) Ziagen 300mg bd 1998 Dec 300mg 600mg
NRTI combinations:       Truvada     Combivir (ZDV/3TC) Epzicom
Kivexa
  Descovy    
Frequency: od bd od od
FDA Approval: 2004 Aug 1997 Sep 2004 Aug 2016 Apr
NNRTIs
nevirapine (NVP) Viramune 200mg bd 1996 Jun 200mg 200mg
delavirdine (DLV) Rescriptor 400mg tds 1997 Apr
efavirenz (EFV) Sustiva 600mg od 1998 Sep 600mg
etravirine (ETR) Intelence 200mg bd 2008 Jan
rilpivirine (RPV) Edurant 25mg od 2011 May 25mg 25mg
Integrase inhibitors
raltegravir (RAL) Isentress 400mg bd 2007 Oct
dolutegravir (DTG) Tivicay 50mg od 2013 Aug 50mg
elvitegravir (EVG) Vitekta 150mg od 2014 Sep 150mg 150mg
Pharmacokinetic enhancer
cobicistat (COBI) Tybost 150mg od 2014 Sep 150mg 150mg
Complete regimens:       Atripla Complera Stribild (QUAD) Trizivir Triumeq Genvoya Odefsey Z250 S30 / S40
Frequency: od od od bd od od od bd bd
FDA Approval: 2006 Jul 2011 Aug 2012 Aug 2000 Nov 2014 Aug 2015 Nov 2016 Mar

 

 

 

Tradename Dose Freq. FDA Approval
PIs (protease inhibitors)
saquinavir (SQV) Invirase 1,000mg bd 1995 Dec
ritonavir (RTV) Norvir 600mg bd 1996 Mar 50mg
indinavir (IDV) Crixivan 800mg tds 1996 Mar
nelfinavir (NFV) Viracept 1,250mg bd 1997 Mar
lopinavir (LPV) 2000 Sep 200mg
atazanavir (ATV) Reyataz 300mg od 2003 Jun 300mg
fosamprenavir (FPV) Lexiva 1,400mg bd 2003 Oct
tipranavir (TPV) Aptivus 500mg bd 2005 Jun
darunavir (DRV) Prezista 800mg od 2006 Jun 800mg
Pharmacokinetic enhancer
cobicistat (COBI) Tybost 150mg od 2014 Sep 150mg 150mg
Boosted PIs:         Kaletra (LPV/r) Evotaz Prezcobix
Frequency: bd od od
FDA Approval: 2000 Sep 2015 Jan 2015 Jan

 

 

References


Blog articles about #HIVtreatment


Related Concepts

Sexual risk (of HIV/STD/pregnancy), and what you can do before and after exposure.

Timeline HIV STD Pregnancy
Before exposure
Abstain from sex, Be faithful, or Condom use
Circumcision (males only)
Contraception
(females only)
HIV PrEP (pre-exposure prophylaxis)
– Stop HIV infection before exposure
STD vaccine:
Hepatitis vaccine
HPV vaccine
STD / HIV exposure
Unsafe sex / unprotected sex:
No condom / Condom broke / Condom slip
0-72 hours HIV PEP (post-exposure prophylaxis)
– Stop HIV infection after exposure
STD testing *
Screening test
– to look for asymptomatic infections
– from previous exposures
Emergency contraception
with the
morning-after pill
(females only)
2 weeks HIV DNA Test
1 month HIV 4th Generation Test
SD Bioline HIV Ag/Ab Combo
– Fingerprick blood sampling.
20 minutes to results
3 months HIV 3rd Generation Test
OraQuick® HIV-1/2 Antibody
– Oral fluid or
– Fingerprick blood sampling.
20 minutes to results
STD testing *
– Full & comprehensive
diagnostic test
– to look for current infections
Watch for HIV Symptoms STD Symptoms
If infected HIV Treatment STD Treatment Abortion

* Males: Do not urinate for at least 4 hours before arriving.
* Females: testing is more accurate when you are not menstruating.


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