Herpes Simplex, Singapore - Shim Clinic
Herpes simplex Singapore: Herpes simplex has 2 varieties. Type 1 and type 2
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Latest NewsT-VEC Immunotherapy Shows Promising Early Activity in Melanoma
Thu, 07 Jun 2018 10:09:17 +0800 | CancerNetwork
Bryant FurlowJun 7, 2018The genetically engineered oncolytic herpes simplex virus produced promising clinical responses in stage IIIB –IVM1a melanoma. (Source: CancerNetwork)
Orajel and Other Teething Medicines Are Not Safe for Babies, FDA Warns
Thu, 24 May 2018 02:10:26 +0800 | TIME: Health
(WASHINGTON) — Federal health officials warned parents Wednesday about the dangers of teething remedies that contain a popular numbing ingredient and asked manufacturers to stop selling their products intended for babies and toddlers. The Food and Drug Administration said that various gels and creams containing the drug benzocaine can cause rare but deadly side effects in children, especially those 2 years and younger. The agency has been warning about the products for a decade but said reports of illnesses and deaths have continued. Now, it wants teething products off the market, noting there is little evidence they actually work. “We urge parents, caregivers and retailers who sell them to heed our warnings and not use over-the-counter products containing benzocaine for teeth...
Mayo Clinic Minute: Stop sharing your lip balm
Fri, 04 May 2018 07:00:00 +0800 | News from Mayo Clinic
Besides the ick factor, Dr. Dawn Davis, a?dermatologist at?Mayo Clinic, says sharing your lip balm or lip moisturizer with another person is a bad idea. Sharing these products increases your risk for contracting?cold sores, which are caused by herpes?simplex virus (HSV-1). Dr. Davis says people can carry the herpes virus in their mouth without developing [...] (Source: News from Mayo Clinic)
Medical News Today: What does eye herpes look like?
Tue, 01 May 2018 05:00:00 +0800 | Health News from Medical News Today
The herpes simplex virus that causes cold sores can also affect the eyes. Herpetic eye disease can lead to sores forming on the eyelid, light sensitivity, and may affect vision. In this article, we examine the ways that herpes affects the eyes and what treatments are available to bring relief. (Source: Health News from Medical News Today)
UCLA study produces clearest images to date of HSV-1, the virus that causes cold sores
Fri, 13 Apr 2018 22:02:52 +0800 | UCLA Newsroom: Health Sciences
UCLA researchers have produced the clearest 3-D images to date of the virus that causes cold sores, herpes simplex virus type 1, or HSV-1. The images enabled them to map the virus ’ structure and offered new insights into how HSV-1 works.A report on the research was published online by the journal Science.The scientists used cryo electron microscopy, or cryoEM, to obtain the first atomic model of the virus particle, which is made up of more than 3,000 protein molecules comprising tens of millions of atoms.“We’ve known that HSV-1 can hide inside the nucleus of the nerve cell and establish life-long latent infection inside most of us,” said Xinghong Dai, a UCLA researcher and the study’s first author. “But it was unclear how the virus travels from the nucleus of a nerve cell, alo...
Cryo-EM structure of a herpesvirus capsid at 3.1 A
Thu, 05 Apr 2018 07:00:00 +0800 | ScienceNOW
Structurally and genetically, human herpesviruses are among the largest and most complex of viruses. Using cryo–electron microscopy (cryo-EM) with an optimized image reconstruction strategy, we report the herpes simplex virus type 2 (HSV-2) capsid structure at 3.1 angstroms, which is built up of about 3000 proteins organized into three types of hexons (central, peripentonal, and edge), pentons, and triplexes. Both hexons and pentons contain the major capsid protein, VP5; hexons also contain a small capsid protein, VP26; and triplexes comprise VP23 and VP19C. Acting as core organizers, VP5 proteins form extensive intermolecular networks, involving multiple disulfide bonds (about 1500 in total) and noncovalent interactions, with VP26 proteins and triplexes that underpin capsid stabilit...
Structure of the herpes simplex virus 1 capsid with associated tegument protein complexes
Thu, 05 Apr 2018 07:00:00 +0800 | ScienceNOW
Herpes simplex viruses (HSVs) rely on capsid-associated tegument complex (CATC) for long-range axonal transport of their genome-containing capsids between sites of infection and neuronal cell bodies. Here we report cryo–electron microscopy structures of the HSV-1 capsid with CATC up to 3.5-angstrom resolution and atomic models of multiple conformers of capsid proteins VP5, VP19c, VP23, and VP26 and tegument proteins pUL17, pUL25, and pUL36. Crowning every capsid vertex are five copies of heteropentameric CATC, each containing a pUL17 monomer supporting the coiled-coil helix bundle of a pUL25 dimer and a pUL36 dimer, thus positioning their flexible domains for potential involvement in nuclear capsid egress and axonal capsid transport. Notwithstanding newly discovered fold conservation...
Thu, 15 Mar 2018 11:00:00 +0800 | EurekAlert! - Infectious and Emerging Diseases
(Harvard Medical School) The ability of the 'cold sore' herpes simplex virus to establish quiet infections and reawaken periodically has long mystified scientists. A new study in mice reveals that a key host protein acts as a critical regulator of the virus's sleep-wake cycle. (Source: EurekAlert! - Infectious and Emerging Diseases)
Molecule halts herpes of the eye
Tue, 27 Feb 2018 07:00:00 +0800 | NIH Research Matters from the National Institutes of Health (NIH)
A small molecule prevents herpes simplex-1 virus from making viral proteins. The finding suggests a new class of molecule that may be useful for developing antiviral treatments. (Source: NIH Research Matters from the National Institutes of Health (NIH))
QuickStats: Age-Adjusted Trends in the Prevalence of Herpes Simplex Virus Type 1 (HSV-1) and Herpes Simplex Virus Type 2 (HSV-2) Among Adolescents and Adults Aged 14 –49 Years — United States, 1999–2000 Through 2015–2016
Fri, 16 Feb 2018 01:00:00 +0800 | CDC Morbidity and Mortality Weekly Report
(Source: CDC Morbidity and Mortality Weekly Report)