Sun Feb 5 00:27:31 SGT 2012  
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Chlamydia | Shim Clinic, STD CLINIC SINGAPORE™

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Summary

Chlamydia | Shim Clinic, STD CLINIC SINGAPORE™: Chlamydia infection symptoms in men/women, screening/diagnosis, testing/check, treatment clinic, Singapore - Private and confidential service. Definitions, references, and latest news.

Description

Chlamydia - discharge from female sex organ The signs appear 1-3 weeks after sexual contact with an infected person.

These include:

  • a yellowish-white discharge from the sex organs
  • a mild burning sensation during urination.
The signs may disappear without treatment. But without treatment, the disease can lead to infertility. An infected woman may infect her newborn during childbirth.

Chlamydia infection is caused by Chlamydia trachomatis and is usually treated with Doxycycline or Azithromycin orally.

References
Latest News

Med Sci Monit 2012; 18(2):BR84-88 "Lack of association of conjunctival MALT lymphoma with Chlamydiae or Helicobacter pylori in a cohort of Chinese patients"
Wed, 01 Feb 2012 05:00:00 +0100 | Medical Science Monitor
Conclusions: The PCR technique was able to detect the positive control quickly and accurately, but the results of PCR in analyzing the 16 specimens were negative, indicating that there is no association between conjunctival MALT lymphoma and the 4 microorganisms in Chinese patients. (Source: Medical Science Monitor)

Dendrimer-Enabled Modulation of Gene Expression in Chlamydia trachomatis
Mon, 30 Jan 2012 16:27:26 +0100 | Molecular Pharmaceutics
Molecular PharmaceuticsDOI: 10.1021/mp200512f (Source: Molecular Pharmaceutics)

Tetracyclines and pain
Thu, 26 Jan 2012 16:45:30 +0100 | Naunyn-Schmiedeberg's Archives of Pharmacology
Abstract  Tetracyclines are natural or semi-synthetic bacteriostatic agents which have been used since late 1940s against a wide range of gram-positive and gram-negative bacteria and atypical organisms such as chlamydia, mycoplasmas, rickettsia, and protozoan parasites. After the discovery of the first tetracyclines, a second generation of compounds was sought in order to improve water solubility for parenteral administration or to enhance bioavailability after oral administration. This approach resulted in the development of doxycycline and minocycline in the 1970s. Doxycycline was included in the World Health Organization Model List of Essential Medicines either as antibacterial or to prevent malaria or to treat patients with this disease. Additional development led to th...

The occurrence of Chlamydia spp. in pigs with and without clinical disease
Thu, 26 Jan 2012 05:00:00 +0100 | BMC Veterinary Research - Latest articles
Conclusions: Chlamydia suis was demonstrated in most samples and overall, no correlation to clinical signs was detected. However, a correlation was noted between samples with a high degree of infection and the presence of clinical signs. It is possible, that the intensive pig production systems studied might predispose for the transmission and maintenance of the infection thus increasing the infectious load and the risk for disease in the pig. (Source: BMC Veterinary Research - Latest articles)

First detection of Chlamydia trachomatis LGV biovar in the Czech Republic, 2010-2011.
Thu, 26 Jan 2012 03:06:03 +0100 | Euro Surveill
Authors: Vanousova D, Zakoucka H, Jilich D, Rozsypal H, Stankova M, Zufanova S, Vojackova N, Hercogova J, Marvan J, Machala L PMID: 22264863 [PubMed - in process] (Source: Euro Surveill)

Evidence That the β Subunit of Chlamydia trachomatis Ribonucleotide Reductase Is Active with the Manganese Ion of Its Manganese(IV)/Iron(III) Cofactor in Site 1
Wed, 25 Jan 2012 18:34:00 +0100 | Journal of the American Chemical Society
Journal of the American Chemical SocietyDOI: 10.1021/ja211314p (Source: Journal of the American Chemical Society)

Diagnostic Characteristics of Tests for Ocular Chlamydia after Mass Azithromycin Distributions [Clinical and Epidemiologic Research]
Wed, 25 Jan 2012 05:00:00 +0100 | Investigative Ophthalmology
Conclusions. Basing treatment decisions after mass azithromycin distributions on the WHO simplified grading system will maximize the treatment of infected persons compared with a DNA-based test but will also result in more uninfected persons being treated. The RNA-based test was considerably more sensitive, and almost equivalently specific, compared with a DNA-based test. (ClinicalTrials.gov number, NCT00322972.) (Source: Investigative Ophthalmology)

Virulence determinants in the obligate intracellular pathogen Chlamydia trachomatis revealed by forward genetic approaches [Microbiology]
Tue, 24 Jan 2012 05:00:00 +0100 | Proceedings of the National Academy of Sciences
Chlamydia trachomatis, a pathogen responsible for diseases of significant clinical and public health importance, remains poorly characterized because of its intractability to routine molecular genetic manipulation. We have developed a combinatorial approach to rapidly generate a comprehensive library of genetically defined mutants. Chemical mutagenesis, coupled with whole-genome sequencing (WGS) and a system for DNA exchange within infected cells, was used to generate Chlamydia mutants with distinct phenotypes, map the underlying genetic lesions, and generate isogenic strains. As a result, we identified mutants with altered glycogen metabolism, including an attenuated strain defective for type II secretion. The coupling of chemically induced gene variation and WGS to establish genotype–p...

Terrence Higgins Trust statement on Public Health Outcomes Framework
Mon, 23 Jan 2012 17:02:12 +0100 | Terrence Higgins Trust
Terrence Higgins Trust's Chief Executive, Sir Nick Partridge, comments on the new Public Health Outcomes Framework published today: ""Poor sexual health is a major concern in the UK so it's vitally important there are specific indicators for both HIV and chlamydia screening. Whilst undiagnosed chlamydia can cause infertility and affects as many as nearly 1 in 15 young people, late diagnosed HIV causes severe ill health, further HIV infections and an earlier death. "These two indicators will tell us whether we are getting our sexual health prevention messages right and whether we are getting enough people through the doors to test. They also give us an opportunity to refresh what we are doing on sexual health in communities, focus on specific local needs and tie approaches in more closely w...


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