HIV PEP Singapore Clinic

References

• HIV PEP - Wikipedia, the free encyclopedia
• HIV PEP: Definition from Answers.com
• HIV PEP - definition of HIV PEP in the Medical dictionary - by the Free Online Medical Dictionary, Thesaurus and Encyclopedia.
• WHO | WHO and HIV
• CDC HIV

Nonoccupational HIV post-exposure prophylaxis: a 10-year retrospective analysis
Thu, 25 Mar 2010 00:00:00 +0100 | HIV Medicine
We conducted a retrospective analysis of administration of nonoccupational HIV post-exposure prophylaxis (nPEP) in a single centre where tracing and testing of the source of exposure were carried out systematically over a 10-year period. Files of all nPEP requests between 1998 and 2007 were reviewed. Characteristics of the exposed and source patients, the type of exposure, and clinical and serological outcomes were analysed. nPEP requests increased by 850% over 10 years. Among 910 events, 58% were heterosexual exposures, 15% homosexual exposures, 6% sexual assaults and 20% nonsexual exposures. In 208 events (23%), the source was reported to be HIV positive. In the remaining cases, active source tracing enabled 298 HIV tests to be performed (42%) and identified 11 HIV infections (3.7%). nPE...

Factors Determining Prenatal HIV Testing for Prevention of Mother to Child Transmission of HIV in Mpumalanga, South Africa
Tue, 05 Jan 2010 06:48:47 +0100 | ---- and Behavior
This study assessed factors associated with participation in HIV counseling and testing and reported reasons for not taking part in Voluntary HIV Counseling and Testing among 930 pregnant women attending clinics for antenatal care in South Africa. Results indicate that from 930 clients interviewed 87% had agreed to participate in individual pre-test HIV counseling and 81.2% had received their test results in post-test counseling. Fear for taking the test, lack of confidentiality and knowing one’s HIV status were the main reasons why women refused to test. In multivariable analysis trust of HCT provider was associated with participation in HIV pre-test counseling and no risky drinking was associated with participation in HIV post-test counseling. These findings suggest mistrust towa...

Serial knife stabbings with HIV exposure – Implications for post-exposure prophylaxis
Fri, 13 Nov 2009 00:00:00 +0100 | Journal of Infection
Summary: Thirty-three persons became victims of a serial knife stabbing incident. One of the first victims one day later disclosed that he was HIV-infected. Thereafter thirty-one victims initiated HIV post-exposure prophylaxis (PEP), one exposed patient declined. None of the victims evaluated had seroconverted six months later. In most such incidents HIV exposure will be difficult to rule out as reliable information on the HIV serostatus of all serial victims will be lacking. It appears prudent, however, to inform serial stab victims about the potential risk of HIV transmission and to at least consider PEP in such scenarios. (Source: Journal of Infection)

Severe synergistic toxicity from docetaxel in a patient treated concurrently with protease inhibitors as part of HIV post-exposure prophylaxis: a case report
Sun, 02 Aug 2009 23:00:00 +0100 | Journal of Medical Case Reports
Conclusion: This case report highlights a probable and novel drug interaction between docetaxel and lopinavir and/or ritonavir, which is largely unreported in the medical literature. Even though these interactions may be more relevant in the field of HIV medicine, knowledge of these interactions is also beneficial to oncologists and dermatologists, as well as those providing acute medical care. (Source: Journal of Medical Case Reports)

Post-exposure prophylaxis
Mon, 29 Jun 2009 16:17:31 +0100 | Medicine
Abstract: UK national guidelines have been issued for the use of antiretroviral drugs as HIV post-exposure prophylaxis (PEP) following occupational exposure in healthcare workers and, in certain circumstances, after sexual exposure. The evidence that PEP is effective is scanty, but prompt antiviral therapy may reduce the risk of HIV transmission by as much as 80%. The decision to prescribe PEP involves risk assessment for the individual patient followed by consideration of the risks and benefits of therapy. For optimal efficacy, antiretroviral therapy should be started as soon as possible, ideally within 1 hour of exposure. PEP starter packs with a 3-day supply of medication should be available in accident and emergency departments, occupational health departments, genitourinary medicine c...

Terrence Higgins Trust and regional partners aim to roll out Play Zone nationally
Tue, 14 Apr 2009 12:33:53 +0100 | Terrence Higgins Trust
After a successful pilot in London and Brighton, Terrence Higgins Trust (THT) is working with a range of regional HIV and sexual health organisations to launch Play Zone across England and Wales. Play Zone is a code of good practice which aims to create a safer environment in venues where sex between men might occur. Play Zone: Code of Good Practice is funded through the national HIV prevention programme. Venues which sign up to the Code pledge to ensure that sexual health, hygiene and health and safety standards are being met.  The Code also aims to raise awareness around sexual health and help to reduce the number of new STI and HIV infections. Saunas and other venues voluntarily participate in the Code giving a clear message that they recognise the importance of providing a safe, clean...

[Research reports] HIV prone occupational exposures: epidemiology and factors associated with initiation of post-exposure prophylaxis
Tue, 14 Apr 2009 04:00:00 +0100 | Journal of Epidemiology and Community Health
Conclusions: PEP-uptake was associated with known transmission risk factors, suggesting awareness of current guidelines. The significant differences in PEP-uptake across occupation categories may be due to differential risk perceptions or other underlying factors. This is the first national study to examine PEP-uptake following occupational exposures to HIV. Further research and exploration of these findings are warranted, to understand the role of PEP-uptake behaviour in preventing occupational HIV transmission. (Source: Journal of Epidemiology and Community Health)

HIV post-exposure prophylaxis in children and adolescents presenting for reported sexual assault.
Tue, 24 Mar 2009 04:00:00 +0100 | Child Abuse & Neglect
CONCLUSIONS: Our results indicate that the prevalence of HIV infection among sexually abused children in our population is low, and follow-up rates are poor. Intensive efforts to try to ensure follow-up are warranted whenever PEP is prescribed. Further research may help better define the efficacy of PEP in sexually abused children and adolescents. PMID: 19324415 [PubMed - as supplied by publisher] (Source: Child Abuse & Neglect)

[PRACTICE] Comprehensive care and HIV prophylaxis after sexual assault in rural South Africa: the Refentse intervention study
Fri, 13 Mar 2009 04:00:00 +0100 | BMJ
Problem Although international guidelines specify the central role of the health sector in providing comprehensive care, including HIV post-exposure prophylaxis (PEP), after sexual assault, in both industrialised and developing countries there are many challenges to providing timely and comprehensive services. Design A nurse driven model of post-rape care was integrated into existing hospital services; the before and after study design evaluated impacts on quality of care, reviewing 334 hospital charts and conducting interviews with 16 service providers and 109 patients. Setting 450 bed district hospital in rural South Africa. Key measures for improvement Quality of care after rape (forensic history and examination, provision of emergency contraception, prophylaxis for sexually transmitted...