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Rabipur® Singapore.

Rabipur® Singapore: Inactivated Rabies Virus vaccine jab/shot/injection schedule, to vaccinate against the Rabies virus, to immunise against Rabies clinic, Singapore. Private and confidential service. Definitions, references, and latest news.

Vaccination against rabies is used in two distinct situations:

  • to protect those who are at risk of exposure to rabies, i.e. pre-exposure vaccination;
  • to prevent the development of clinical rabies after exposure has occurred, usually following the bite of an animal suspected of having rabies, i.e. postexposure prophylaxis.
The vaccines used for pre-exposure and post-exposure vaccination are the same, but the immunization schedule differs. Rabies immunoglobulin is used only for post-exposure prophylaxis. Modern vaccines of cell-culture or embryonated-egg origin are safer and more effective than the older vaccines, which were produced in brain tissue. These modern rabies vaccines are now available in major urban centres of most countries of the developing world. Rabies immunoglobulin, on the other hand, is in short supply worldwide and may not be available, even in major urban centres, in many dog rabiesinfected countries.

Pre-exposure vaccination

Pre-exposure vaccination should be offered to people at high risk of exposure to rabies, such as laboratory staff working with rabies virus, veterinarians, animal handlers and wildlife officers, and other individuals living in or travelling to countries or areas at risk. Travellers with extensive outdoor exposure in rural areas — such as might occur while running, bicycling, hiking, camping, backpacking, etc. — may be at risk, even if the duration of travel is short. Pre-exposure vaccination is advisable for children living in or visiting countries or areas at risk, where they provide an easy target for rabid animals. Pre-exposure vaccination is also recommended for individuals travelling to isolated areas or to areas where immediate access to appropriate medical care is limited or to countries or areas where modern rabies vaccines are in short supply and locally available rabies vaccines might be unsafe and/or ineffective.

Pre-exposure rabies vaccination consists of three full intramuscular doses of cell-culture- or embryonated-egg-based vaccine given on days 0, 7 and 21 or 28 (a few days' variation in the timing is not important). For adults, the vaccine should always be administered in the deltoid area of the arm; for young children (under 1 years of age), the anterolateral area of the thigh is recommended. Rabies vaccine should never be administered in the gluteal area: administration in this manner will result in lower neutralizing antibody titres.

To reduce the cost of cell-derived vaccines for pre-exposure rabies vaccination, intradermal vaccination in 0.1-ml volumes on days 0, 7 and either 21 or 28 may be considered. This method of administration is an acceptable alternative to the standard intramuscular administration, but it is technically more demanding and requires appropriate staff training and qualified medical supervision. Concurrent use of chloroquine can reduce the antibody response to intradermal application of cell-culture rabies vaccines. People who are currently receiving malaria prophylaxis or who are unable to complete the entire three-dose pre-exposure series before starting malarial prophylaxis should therefore receive pre-exposure vaccination by the intramuscular route.

Periodic booster injections are therefore not recommended for general travellers. However, in the event of exposure through the bite or scratch of an animal known or suspected to be rabid, individuals who have previously received a complete series of pre- or post-exposure rabies vaccine (with cell-culture or embryonated-egg vaccine) should receive two booster doses of vaccine. Ideally, the first dose should be administered on the day of exposure and the second 3 days later. This should be combined with thorough wound treatment (see “Post-exposure prophylaxis”, below). Rabies immunoglobulin is not required for previously vaccinated patients.

Precautions and contraindications

Modern rabies vaccines are well tolerated. The frequency of minor adverse reactions (local pain, erythema, swelling and pruritus) varies widely from one report to another. Occasional systemic reactions (malaise, generalized aches and headaches) have been noted after both intramuscular and intradermal injections.

Type of vaccine: Modern cell-culture or embryonated-egg vaccine

Number of doses: Three, one on each of days 0, 7 and 21 or 28, given i.m. (1 or 0.5 ml/dose depending on the vaccine) or i.d. (0.1 ml/ inoculation site)a

Booster: Not routinely needed for general travellersb

Adverse reactions: Minor local or systemic reactions

Before departure: Pre-exposure prophylaxis for those planning a visit to a country or area at risk, especially if the area to be visited is far from major urban centres and appropriate care, including the availability of post-exposure rabies prophylaxis, cannot be assured.


a For information on which vaccines are recommended for intradermal use, see: http://www.who.int/rabies/human/postexp/en/index.html.

b In the event of exposure through the bite or scratch of an animal known or suspected to be rabid, individuals who have previously received a complete series of pre-exposure or post-exposure cell-culture or embryonated-egg rabies vaccine should receive two booster doses of vaccine, the first dose ideally on the day of exposure and the second 3 days later. Rabies immunoglobulin should not be administered.

Post-exposure prophylaxis

In countries or areas at risk of rabies, the circumstances of an animal bite or other contact with an animal suspected to be rabid may require postexposure prophylaxis. In such situations, medical advice should be obtained immediately.

Strict adherence to the WHO-recommended guidelines for optimal post-exposure rabies prophylaxis virtually guarantees protection from the disease. The administration of vaccine, and immunoglobulin if required, must be conducted by, or under the direct supervision of, a physician. Post-exposure prophylaxis depends on the type of contact with the confirmed or suspect rabid animal, as follows:


a Exposure to rodents, rabbits and hares seldom, if ever, requires specific anti-rabies post-exposure prophylaxis.

b If an apparently healthy dog or cat in or from a low-risk country or area is placed under observation, the situation may warrant delaying initiation of treatment.

c This observation period applies only to dogs and cats. Except in the case of threatened or endangered species, other domestic and wild animals suspected to be rabid should be humanely killed and their tissues examined for the presence of rabies antigen using appropriate laboratory techniques.

d Post-exposure prophylaxis should be considered for individuals who have been in close contact with bats, particularly following bites or scratches or exposure to mucous membranes.

1. Wound treatment

Thorough washing of the wound with soap/detergent and water, followed by the application of ethanol or an aqueous solution of iodine or povidone.

2. Passive immunization

Human rabies immunoglobulin (HRIG) or equine rabies immunoglobulin (ERIG) or F(ab')2 products for category III exposures as well as some category II exposures (see table, above). Passive immunization should be administered just before or shortly after administration of the first dose of vaccine given in the post-exposure prophylaxis regimen. If it is not immediately available, passive immunization can be administered up until the seventh day after initiation of the primary series of post-exposure prophylaxis (with cell-culture or embryonated-egg rabies vaccine).

Dosage and administration: The dose for HRIG is 20 IU/kg body weight and for ERIG and F(ab')2 products 40 IU/kg body weight. The full dose of rabies immunoglobulin, or as much as is anatomically feasible, should be administered into and around the wound site. Any remainder should be injected i.m. at a site distant from the site of active vaccine administration. Multiple needle injections into the wound should be avoided. If the correct dose of rabies immunoglobulin is too small to infiltrate all wounds, as might be true of a severely bitten individual, it can be diluted in physiological buffered saline to ensure greater wound coverage.

3. Active immunization

Cell-culture- or embryonated-egg-based rabies vaccines should always be used for post-exposure prophylaxis. They can be administered either i.m. or i.d.

Intramuscular regimens: Both a five-dose and a four-dose i.m. regimen are recommended for post-exposure vaccination; the five-dose (“Essen”) regimen is the more commonly used:

  • The five-dose regimen is administered on days 0, 3, 7, 14 and 28 into the deltoid muscle.
  • The four-dose regimen is administered as two doses on day 0 (one dose in the right and one in the left deltoid), and then one dose on each of days 7 and 21 into the deltoid muscle.
An alternative post-exposure regimen for healthy, fully immunocompetent exposed people who receive wound care plus high-quality rabies immunoglobulin plus WHO-prequalified rabies vaccines consists of four doses administered i.m. on days 0, 3, 7 and 14.

Intradermal regimens: Intradermal administration of cell-culture- and embryonated- egg-based rabies vaccines has been successfully used in many developing countries that cannot afford the five- or four-dose i.m. schedules.

  • The two-site i.d. method: one i.d. injection at two sites on days 0, 3, 7 and 28.
For use with: 0.1 ml for purified Vero cell rabies vaccine; 0.1 ml for purified chick embryo rabies vaccine.

Vaccine types available for vaccination / immunisation (uk) / immunization (us) :

Vaccine Against Disease Age D
o
s
e
s
Dose schedule Price
per
dose
(SG$)
Live attenuated
MMR vaccine ≥12m 1 $70/=
Measles virus Measles
Mumps virus Mumps
Rubella virus Rubella
Varilrix™ Varicella zoster virus
HHV-3
Varicella Chickenpox 12m-12y 1 $95/=
≥13y 2 6-10w interval
Zostavax™ Herpes zoster Shingles ≥50y 1 $295/=
Stamaril® Yellow fever virus Yellow fever 9m-59y 1 10 yearly $250/=
Inactivated / Whole / Viral & Bacterial
Rabipur® Rabies virus Rabies any 3 d 0, 7, & 21 or 28 $call/=
Ixiaro® Japanese encephalitis virus Japanese encephalitis ≥17y 2 2nd: 28d after 1st $386/=
1 Booster: 12-24m after 2nd
Dukoral® Vibrio cholerae Cholera 2-6y 3 1-6w interval $113/=
1 Booster: 6m after 3rd
≥6y 2 1-6w interval
1 Booster: 2y after 2nd
Inactivated / Fractional / Protein
Intanza™ Influenza virus Influenza 18-59y 1 1 yearly $30/=
Fluarix™ Influenza virus Influenza 6-36m ½ 1 yearly $30/=
>3y 1
Tetavax Clostridium tetani Tetanus adults 3 1-2m interval
3rd @ 6-12m
after 2nd
$30/=
booster 1 10 yearly
Boostrix® ≥4y 1 <10 yearly $70/=
Corynebacterium diphtheriae Diphtheria
Clostridium tetani Tetanus
Bordetella pertussis Pertussis
Whooping cough
Inactivated / Fractional / Polysaccharide / Pure
Typhim Vi® Salmonella typhi Typhoid fever >5y 1 3 yearly $48/=
Mencevax® ACWY Neisseria meningitidis
types A, C, W-135
and Y
Meningococcal meningitis >2y 1 $80/=
Inactivated / Fractional / Polysaccharide / Conjugate
Menactra® Neisseria meningitidis
types A, C, W-135
and Y
Meningococcal meningitis 2-55y 1 $195/=
Prevenar 13® (SG) /
Prevnar 13® (US)
Streptococcus pneumoniae
types 1, 3, 4, 5,
6A, 6B, 7F, 9V, 14,
18C, 19A, 19F, 23F
Pneumococcal infection 6w-6m 4 1m interval
4th @ 12-15m
$274/=
7-11m 2 1m interval
12-23m 2 2m interval
2-5y 1
≥50y 1

If the clinic attendance is just for vaccination alone, no additional consultation fees are charged.

Testing for immunity against the following is available:

Virus Antibody Test Price
Varicella zoster virus Varicella Zoster IgG Antibody $44/=
Measles virus Measles IgG Antibody $90/=
Rubella virus Rubella IgG Antibody $24/=
Hepatitis A virus Hepatitis A IgG Antibody $30/=
Hepatitis B virus Hepatitis B surface Antibody $10/=

Other vaccines not stocked

References Vaccine Classification References Hajj vaccine / Haj vaccine / Umrah vaccine requirements for travel to Mecca, Saudi Arabia: References STD vaccine / hepatitis vaccine shot/jab/injection to prevent some STDs

Vaccine Against Disease Age D
o
s
e
s
Dose schedule Price
per
dose
(SG$)
Havrix™ 1440 Adult Hepatitis A virus Hepatitis A ≥19y 2 m 0 & 6-12 $90/=
Twinrix® Hepatitis A virus
Hepatitis B virus
Hepatitis A
Hepatitis B
1-15y 2 m 0, 6-12 $135/=
≥16y 3 m 0, 1, 6
4 d 0, 7, 21 & m 12
Inactivated / Fractional / Protein / Subunit / Recombinant
Engerix™-B 20 μg Hepatitis B virus Hepatitis B 11-15y 2 m 0, & 6 $50/=
≥20y 3 m 0, 1, & 6
4 m 0, 1, 2, & 12 or
d 0, 7, 21 & m 12
Gardasil® HPV
types 6, 11, 16, & 18
Genital warts
Cervical cancer
9-26y 3 m 0, 2, & 6 or
m 0, 1, & 4
$195/=
Cervarix® HPV
types 16, & 18
(31, 33, & 45)
10-25y 3 m 0, 1, & 6
m 0, 1, & 5
m 0, 2½, 12
$195/=
V503 HPV
types 6, 11, 16, 18,
31, 33, 45,
52, & 58
3 m 0, 2, & 6 or
m 0, 1, & 4
$???/=

Vaccine schedule / vaccination schedule / immunisation schedule / immunization schedule :

Annex A

National Childhood and Adolescent Immunisation Schedule, Singapore
For persons aged 0 to <18 years

Vaccination against Birth 1 month 3 months 4 months 5 months 6 months 12 months 15 months 18 months 6-7 years^ 10-11 years^^
Tuberculosis BCG
Hepatitis B HepB (D1) HepB (D2) HepB (D3)#
Diphtheria, Tetanus, Pertussis DTaP (D1) DTaP (D2) DTaP (D3) DTaP (B1) Tdap (B2)
Poliovirus OPV (D1) OPV (D2) OPV (D3) OPV (B1) OPV (B2) OPV (B3)
Measles, Mumps, Rubella MMR (D1) MMR (D2)##
Pneumococcal Disease PCV (D1) PCV (D2) PCV (B1)
Human Papillomavirus Recommended for females 9 to 26 years; three doses are required at intervals of 0, 2, 6 months
Influenza Recommended annually for all children aged 6 months to <5 years and children aged 6 months to <18 years in high-risk groups

 
Notes:
BCG Bacillus Calmette-Guérin
HepB Hepatitis B vaccine
DTaP Paediatric diphtheria and tetanus toxoid and acellular pertussis vaccine
Tdap Tetanus toxoid, reduced diphtheria toxoid and acellular pertussis vaccine
MMR Measles, mumps, and rubella vaccine
OPV Oral polio vaccine
PCV Pneumococcal conjugate vaccine
D1/D2/D3 1st dose, 2nd dose, 3rd dose
B1/B2/B3 1st booster, 2nd booster, 3rd booster
^ Primary 1
^^ Primary 5
 
# 3rd dose of HepB can be given with the 3rd dose of DTaP and OPV for the convenience of parents.
## 2nd dose of MMR can be given between 15-18 months
 

References:

We offer teenage, adult and travel vaccination. Vaccines from the above list that we have are:


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