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Ixiaro® Singapore.

Ixiaro® Singapore: Inactivated attenuated Japanese encephalitis virus strain SA14-14-2 vaccine jab/shot/injection schedule, to vaccinate against the Japanese encephalitis virus (JEV), to immunise against Japanese encephalitis (JE) clinic, Singapore. Private and confidential service. Definitions, references, and latest news.

The inactivated mouse-brain-derived (IMB) vaccine is now commonly replaced by cell-culture-based vaccines. The live attenuated SA 14-14-2 vaccine is widely used in China and in an increasing number of countries within the Asian region, including India, the Republic of Korea, Sri Lanka, and Thailand.

A Vero cell-derived, inactivated JE vaccine was approved in 2009 in North America, Australia and various European countries. The vaccine is based on the attenuated SA 14-14-2 JE viral strain, inactivated and alum-adjuvanted. The primary two doses are administered 4 weeks apart. A booster dose is recommended 1–2 years after the primary immunization. This vaccine has been given concomitantly with hepatitis A vaccine without significant interference with safety and immunogenicity. Data on concomitant administration with other vaccines frequently used in travellers are currently unavailable. The vaccine is licensed for use in individuals 17 years of age and older in the United States, and 18 years and above in other countries. Post-marketing safety studies are under way.

Another Vero cell-derived inactivated JE vaccine was licensed by the Japanese authorities in February 2009 and a similar vaccine was licensed in 2011. These two vaccines use the same strain of JE virus (Beijing-1) as the mouse-brain-derived vaccine. Clinical trials have shown that the vaccines are safe and immunogenic, with seroconversion rates exceeding 95%. Theses vaccines are currently not available outside Japan.

In addition, a new live attenuated, JE-yellow fever chimeric vaccine has recently been licensed in Australia and Thailand , and will be commercialized from 2012. This vaccine requires a single dose for primary immunization; the possible need for booster doses remains to be determined.

Precautions and contraindications

A hypersensitivity reaction to a previous dose is a contraindication. The live attenuated vaccine should be avoided in pregnancy unless the likely risk favours its administration. Rare, but serious, neurological adverse events attributed to IMB vaccine have been reported from countries or areas at risk as well as from non-risk countries or areas. Allergic reactions to components of the vaccine occur occasionally. As such reactions may occur up to 2 weeks after administration, it is advisable to ensure that the complete course of vaccine is administered well in advance of departure.

Type of vaccine:
1) Live attenuated vaccine (SA 14-14-2 strain)
2) Inactivated, Vero cell-derived, alum-adjuvanted vaccine (SA 14-14-2 strain)
3) Inactivated Vero cell-derived based vaccines (Beijing-1 strain)

Schedule:
1) In China, the first dose of the live attenuated vaccine is given subcutaneously at age 8 months, followed by a booster dose at 2 years of age. In some areas, an additional booster is offered at 6–7 years of age. Protection for several years may be achieved also with a single dose of this vaccine.
2) Primary immunization of the inactivated, alum-adjuvanted vaccine consists of two intramuscular doses, 4 weeks apart
3) The inactivated (Bejjing-1-) vaccines: three doses at days 0, 7 and 28, or two doses given preferably 4 weeks apart (0.25 ml for children <3 years, 0.5 ml for all other ages).

Booster: The duration of immunity is not well established for the above vaccines. For 1) the live attenuated vaccine, a booster dose is recommended in some countries. For 2) the Japanese vaccines, a booster is recommended after year 1, and thereafter every 3 years. For 3) the inactivated, alum-adjuvanted vaccine, one booster is recommended 12–14 months after completion of the primary immunization; the possible need for further boosters to be determined.

Contraindications: For all JE vaccines: hypersensitivity to a previous dose of vaccine. For live JE vaccine: pregnancy and immunosuppression.

Adverse reactions: Occasional mild local or systemic reactions

Before departure: The immunization series should be completed at least 1 week before potential exposure to JEV.

Special precautions: With the inactivated, alum-adjuvanted, Vero cell-derived SA14-14-2 vaccine, safety and effectiveness have not been established in pregnant women, in nursing mothers, or in children and adolescents (younger than 17 years of age).

Vaccine types available for vaccination / immunisation (uk) / immunization (us) :

Vaccine Against Disease Age D
o
s
e
s
Dose schedule Price
per
dose
(SG$)
Live attenuated
MMR vaccine ≥12m 1 $70/=
Measles virus Measles
Mumps virus Mumps
Rubella virus Rubella
Varilrix™ Varicella zoster virus
HHV-3
Varicella Chickenpox 12m-12y 1 $95/=
≥13y 2 6-10w interval
Zostavax™ Herpes zoster Shingles ≥50y 1 $295/=
Stamaril® Yellow fever virus Yellow fever 9m-59y 1 10 yearly $250/=
Inactivated / Whole / Viral & Bacterial
Rabipur® Rabies virus Rabies any 3 d 0, 7, & 21 or 28 $call/=
Ixiaro® Japanese encephalitis virus Japanese encephalitis ≥17y 2 2nd: 28d after 1st $386/=
1 Booster: 12-24m after 2nd
Dukoral® Vibrio cholerae Cholera 2-6y 3 1-6w interval $113/=
1 Booster: 6m after 3rd
≥6y 2 1-6w interval
1 Booster: 2y after 2nd
Inactivated / Fractional / Protein
Intanza™ Influenza virus Influenza 18-59y 1 1 yearly $30/=
Fluarix™ Influenza virus Influenza 6-36m ½ 1 yearly $30/=
>3y 1
Tetavax Clostridium tetani Tetanus adults 3 1-2m interval
3rd @ 6-12m
after 2nd
$30/=
booster 1 10 yearly
Boostrix® ≥4y 1 <10 yearly $70/=
Corynebacterium diphtheriae Diphtheria
Clostridium tetani Tetanus
Bordetella pertussis Pertussis
Whooping cough
Inactivated / Fractional / Polysaccharide / Pure
Typhim Vi® Salmonella typhi Typhoid fever >5y 1 3 yearly $48/=
Mencevax® ACWY Neisseria meningitidis
types A, C, W-135
and Y
Meningococcal meningitis >2y 1 $80/=
Inactivated / Fractional / Polysaccharide / Conjugate
Menactra® Neisseria meningitidis
types A, C, W-135
and Y
Meningococcal meningitis 2-55y 1 $195/=
Prevenar 13® (SG) /
Prevnar 13® (US)
Streptococcus pneumoniae
types 1, 3, 4, 5,
6A, 6B, 7F, 9V, 14,
18C, 19A, 19F, 23F
Pneumococcal infection 6w-6m 4 1m interval
4th @ 12-15m
$274/=
7-11m 2 1m interval
12-23m 2 2m interval
2-5y 1
≥50y 1

If the clinic attendance is just for vaccination alone, no additional consultation fees are charged.

Testing for immunity against the following is available:

Virus Antibody Test Price
Varicella zoster virus Varicella Zoster IgG Antibody $44/=
Measles virus Measles IgG Antibody $90/=
Rubella virus Rubella IgG Antibody $24/=
Hepatitis A virus Hepatitis A IgG Antibody $30/=
Hepatitis B virus Hepatitis B surface Antibody $10/=

Other vaccines not stocked

References Vaccine Classification References Hajj vaccine / Haj vaccine / Umrah vaccine requirements for travel to Mecca, Saudi Arabia: References STD vaccine / hepatitis vaccine shot/jab/injection to prevent some STDs

Vaccine Against Disease Age D
o
s
e
s
Dose schedule Price
per
dose
(SG$)
Havrix™ 1440 Adult Hepatitis A virus Hepatitis A ≥19y 2 m 0 & 6-12 $90/=
Twinrix® Hepatitis A virus
Hepatitis B virus
Hepatitis A
Hepatitis B
1-15y 2 m 0, 6-12 $135/=
≥16y 3 m 0, 1, 6
4 d 0, 7, 21 & m 12
Inactivated / Fractional / Protein / Subunit / Recombinant
Engerix™-B 20 μg Hepatitis B virus Hepatitis B 11-15y 2 m 0, & 6 $50/=
≥20y 3 m 0, 1, & 6
4 m 0, 1, 2, & 12 or
d 0, 7, 21 & m 12
Gardasil® HPV
types 6, 11, 16, & 18
Genital warts
Cervical cancer
9-26y 3 m 0, 2, & 6 or
m 0, 1, & 4
$195/=
Cervarix® HPV
types 16, & 18
(31, 33, & 45)
10-25y 3 m 0, 1, & 6
m 0, 1, & 5
m 0, 2½, 12
$195/=
V503 HPV
types 6, 11, 16, 18,
31, 33, 45,
52, & 58
3 m 0, 2, & 6 or
m 0, 1, & 4
$???/=

Vaccine schedule / vaccination schedule / immunisation schedule / immunization schedule :

Annex A

National Childhood and Adolescent Immunisation Schedule, Singapore
For persons aged 0 to <18 years

Vaccination against Birth 1 month 3 months 4 months 5 months 6 months 12 months 15 months 18 months 6-7 years^ 10-11 years^^
Tuberculosis BCG
Hepatitis B HepB (D1) HepB (D2) HepB (D3)#
Diphtheria, Tetanus, Pertussis DTaP (D1) DTaP (D2) DTaP (D3) DTaP (B1) Tdap (B2)
Poliovirus OPV (D1) OPV (D2) OPV (D3) OPV (B1) OPV (B2) OPV (B3)
Measles, Mumps, Rubella MMR (D1) MMR (D2)##
Pneumococcal Disease PCV (D1) PCV (D2) PCV (B1)
Human Papillomavirus Recommended for females 9 to 26 years; three doses are required at intervals of 0, 2, 6 months
Influenza Recommended annually for all children aged 6 months to <5 years and children aged 6 months to <18 years in high-risk groups

 
Notes:
BCG Bacillus Calmette-Guérin
HepB Hepatitis B vaccine
DTaP Paediatric diphtheria and tetanus toxoid and acellular pertussis vaccine
Tdap Tetanus toxoid, reduced diphtheria toxoid and acellular pertussis vaccine
MMR Measles, mumps, and rubella vaccine
OPV Oral polio vaccine
PCV Pneumococcal conjugate vaccine
D1/D2/D3 1st dose, 2nd dose, 3rd dose
B1/B2/B3 1st booster, 2nd booster, 3rd booster
^ Primary 1
^^ Primary 5
 
# 3rd dose of HepB can be given with the 3rd dose of DTaP and OPV for the convenience of parents.
## 2nd dose of MMR can be given between 15-18 months
 

References:

We offer teenage, adult and travel vaccination. Vaccines from the above list that we have are:


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