Vardenafil | Shim Clinic, MEN'S CLINIC SINGAPORE™

Vardenafil | Shim Clinic, MEN'S CLINIC SINGAPORE™: Male impotence, sexual/erectile dysfunction (ED) symptoms, treatment, drugs/medication clinic, Singapore. Private and confidential service. Definitions, references, and latest news.

Description

Table of Contents

• Erectile Dysfunction (ED) (Sexual Dysfunction / Impotence)
• Erectile Dysfunction Treatment (Impotence Treatment)

• Sildenafil (Viagra®)
• Vardenafil (Levitra®)
• Tadalafil (Cialis®)

Erectile dysfunction may be assessed with the international index of erectile function (IIEF-5) a.k.a. sexual health inventory for men (SHIM), and an erectile dysfunction diagnosis made:

The IIEF-5 questionnaire^a

Over the past six months:
1	How do you rate your confidence that you could get and keep an erection?	Very low	Low	Moderate	High	Very high
		1	2	3	4	5
2	When you had erections with sexual stimulation, how often were your erections hard enough for penetration?	Almost never/never	A few times (much less than half the time)	Sometimes (about half the time)	Most times (much more than half the time)	Almost always/always
		1	2	3	4	5
3	During sexual intercourse, how often were you able to maintain your erection after you had penetrated (entered) your partner?	Almost never/never	A few times (much less than half the time)	Sometimes (about half the time)	Most times (much more than half the time)	Almost always/always
		1	2	3	4	5
4	During sexual intercourse, how difficult was it to maintain your erection to completion of intercourse?	Extremely difficult	Very difficult	Difficult	Slightly difficult	Not difficult
		1	2	3	4	5
5	When you attempted sexual intercourse, how often was it satisfactory for you?	Almost never/never	A few times (much less than half the time)	Sometimes (about half the time)	Most times (much more than half the time)	Almost always/always
		1	2	3	4	5

^aThe IIEF-5 score is the sum of the ordinal responses to the five items; thus, the score can range from 5 to 25.
ED severity: severe (5-7), moderate (8-11), mild to moderate (12-16), mild (17-21), and no ED (22-25)

Men's health issues:

• Erectile dysfunction (ED)
• Premature ejaculation (PE)
• Andropause
• Androgenic alopecia
• STD (Sexually transmitted disease)

• Vardenafil - Wikipedia, the free encyclopedia
• Vardenafil: Definition from Answers.com
• Vardenafil - definition of Vardenafil in the Medical dictionary - by the Free Online Medical Dictionary, Thesaurus and Encyclopedia.
• RC Rosen, JC Cappelleri, MD Smith, J Lipsky and BM Pena. Development and evaluation of an abridged, 5-item version of the International Index of Erectile Function (IIEF-5) as a diagnostic tool for erectile dysfunction International Journal of Impotence Research (1999) 11, 319-326

PDE5 inhibitors, ---------- and ----------, reverse multidrug resistance by inhibiting the efflux function of MRP7 (ABCC10) transporter
Fri, 11 May 2012 04:00:00 +0100 | Cancer Science
SummaryPhosphodiesterase type 5 (PDE5) inhibitors are widely used in the treatment of male erectile dysfunction and in improving the breathing efficiency in pulmonary hypertension. Recently, several groups have evaluated the ability of PDE5 inhibitors for their anticancer activities. Previously, we have shown that ----------, ---------- and --------- could reverse P‐glycoprotein (P‐gp, ABCB1)‐mediated multidrug resistance (MDR). In the present study, we determined whether these PDE5 inhibitors have the potential to reverse multidrug resistance protein 7 (MRP7, ABCC10)‐mediated MDR. We found that ---------- and ---------- dose‐dependently enhanced the sensitivity of MRP7‐transfected HEK293 cells to paclitaxel, docetaxel and vinblastine, while --------- had only minimal effect. A...

Monthly News Round Up - April 2012
Mon, 30 Apr 2012 23:04:24 +0100 | Drugs.com - Pharma News
Stendra: Another Option for Erectile Dysfunction is Approved Joining the ranks of ------ (silenafil), ------ (---------), and ------- (----------), another phosphodiesterase type 5 (PDE5) inhibitor for erectile dysfunction (ED) by the brand name... (Source: Drugs.com - Pharma News)

Effects of Chronic ---------- Treatment Persist after End of Treatment in Rats with Acute Arteriogenic Erectile Dysfunction
Mon, 30 Apr 2012 04:00:00 +0100 | The Journal of Sexual Medicine
Conclusions.  The effects of chronic ---------- treatment on erectile function and penile structure persist, even after the end of treatment, in acute arteriogenic ED rats. Hotta Y, Ohno R, Kataoka T, Mikumo M, Takahata Y, Ohno M, Maeda Y, and Kimura K. Effects of chronic ---------- treatment persist after end of treatment in rats with acute arteriogenic erectile dysfunction. J Sex Med **;**:**–**. (Source: The Journal of Sexual Medicine)

STAXYN (---------- Hydrochloride) Tablet, Orally Disintegrating [Physicians Total Care, Inc.]
Thu, 26 Apr 2012 05:00:00 +0100 | DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST)
Updated Date: Apr 26, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Acute hemodynamic response in relation to plasma ---------- levels in patients with Pulmonary Hypertension
Fri, 20 Apr 2012 19:00:26 +0100 | British Journal of Clinical Pharmacology
Conclusions:  ---------- causes rapid changes in cardiopulmonary hemodynamics, and there is a correlation between plasma ---------- drug concentration and the acute changes in mPAP as well as PVR in patients with PH.© 2012 The Authors. British Journal of Clinical Pharmacology © 2012 The British Pharmacological Society (Source: British Journal of Clinical Pharmacology)

A Randomized, Placebo‐Controlled Study to Assess Safety and Efficacy of ---------- 10 mg and Tamsulosin 0.4 mg vs. Tamsulosin 0.4 mg Alone in the Treatment of Lower Urinary Tract Symptoms Secondary to Benign Prostatic Hyperplasia
Tue, 17 Apr 2012 04:00:00 +0100 | The Journal of Sexual Medicine
Conclusions.  The combination of tamsulosin and ---------- for 12 weeks was well tolerated and more effective to improve both LUTS and erectile function, as compared with tamsulosin alone. Further studies are needed to assess the role of combined therapy of phosphodiesterase type 5 inhibitors and alpha blockers in treating LUTS/BPH. Gacci M, Vittori G, Tosi N, Siena G, Rossetti MA, Lapini A, Vignozzi L, Serni S, Maggi M, and Carini M. A randomized, placebo‐controlled study to assess safety and efficacy of ---------- 10 mg and tamsulosin 0.4 mg vs. tamsulosin 0.4 mg alone in the treatment of lower urinary tract symptoms secondary to benign prostatic hyperplasia. J Sex Med **;**:**–**. (Source: The Journal of Sexual Medicine)

---------/----------: Central serous chorioretinopathy (first report with ----------): 2 case reports
Sun, 08 Apr 2012 15:14:59 +0100 | Reactions
(Source: Reactions)

Nitric oxide synthases: regulation and function
Sun, 01 Apr 2012 04:00:00 +0100 | European Heart Journal
Nitric oxide (NO), the smallest signalling molecule known, is produced by three isoforms of NO synthase (NOS; EC 1.14.13.39). They all utilize l-arginine and molecular oxygen as substrates and require the cofactors reduced nicotinamide-adenine-dinucleotide phosphate (NADPH), flavin adenine dinucleotide (FAD), flavin mononucleotide (FMN), and (6R-)5,6,7,8-tetrahydrobiopterin (BH4). All NOS bind calmodulin and contain haem. Neuronal NOS (nNOS, NOS I) is constitutively expressed in central and peripheral neurons and some other cell types. Its functions include synaptic plasticity in the central nervous system (CNS), central regulation of blood pressure, smooth muscle relaxation, and vasodilatation via peripheral nitrergic nerves. Nitrergic nerves are of particular importance in the relaxation...

Increasing the Dose of ---------- on a Daily Basis Does Not Improve Erectile Function after Unilateral Nerve‐Sparing Radical Prostatectomy
Thu, 29 Mar 2012 04:00:00 +0100 | The Journal of Sexual Medicine
Conclusions.  Daily low‐dose ---------- lead to significant improvement of recovery of EF. In this study doubling the dosage did not improve the recovery of EF further. Bannowsky A, van Ahlen H, Loch T. Increasing the dose of ---------- on a daily basis does not improve erectile function after unilateral nerve‐sparing radical prostatectomy. J Sex Med **;**:**–**. (Source: The Journal of Sexual Medicine)

ABOUT TRUST ONLINE