Trichomoniasis | Shim Clinic, STD CLINIC SINGAPORE™

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Summary

Trichomoniasis | Shim Clinic, STD CLINIC SINGAPORE™: Trichomoniasis symptoms in men/women, screening/diagnosis, testing/check, treatment clinic, Singapore - Private and confidential service. Definitions, references, and latest news.

Description

Trichomoniasis is caused by Trichomonas vaginalis, is occasionally symptomatic, foul-smelling, and is usually treated with Metronidazole or Tinidazole orally.

References

• Trichomoniasis - Wikipedia, the free encyclopedia
• Trichomoniasis: Definition from Answers.com
• Trichomoniasis - definition of Trichomoniasis in the Medical dictionary - by the Free Online Medical Dictionary, Thesaurus and Encyclopedia.
• WHO | Trichomoniasis treatment in women
• Trichomoniasis - STD information from CDC

Determinants of Per-Coital-Act HIV-1 Infectivity Among African HIV-1-Serodiscordant Couples.
Fri, 20 Jan 2012 03:32:13 +0100 | Herpes
Conclusions. Modifiable risk factors for HIV-1 transmission were plasma HIV-1 RNA level and condom use, and, in HIV-1-uninfected partners, herpes simplex virus 2 infection, genital ulcers, Trichomonas vaginalis, vaginitis or cervicitis, and male circumcision. PMID: 22241800 [PubMed - as supplied by publisher] (Source: Herpes)

The role of sexually transmitted infections in the evolution of the South African HIV epidemicRôle des infections sexuellement transmissibles dans l’évolution de l’épidémie du VIH en Afrique du sudEl papel de las infecciones de transmisión sexual en la evolución de la epidemia de VIH en Sudáfrica
Thu, 19 Jan 2012 09:54:07 +0100 | Tropical Medicine and International Health
Conclusions  Sexually transmitted infections have contributed significantly to the spread of HIV in South Africa, but STI control efforts have had limited impact on HIV incidence because of their late introduction and suboptimal coverage.Objectifs:  Evaluer la mesure dans laquelle les infections sexuellement transmissibles (IST) ont contribuéà la propagation du VIH en Afrique du sud et estimer dans quelle mesure des améliorations dans le traitement des IST ont réduit l’incidence du VIH.Méthodes:  Un modèle mathématique a été utilisé pour simuler les interactions entre le VIH et six autres IST (herpès génital, syphilis, chancre mou, blennorragie, infection à Chlamydia et à Trichomonas) ainsi que la vaginose bactérienne et la candidose vaginale. Les effets des IST sur ...

Lycorine derivatives against Trichomonas vaginalis
Thu, 19 Jan 2012 05:00:00 +0100 | Chemical Biology and Drug Design
Six lycorine derivatives were prepared, characterized and evaluated for their in vitro anti‐Trichomonas vaginalis activity. Compounds bearing an acetyl (2), lauroyl (3), benzoyl (4 and 5) and p‐nitrobenzoyl (6 and 7) groups were synthesized. The best activity was achieved with lycorine esterified at C‐2 position with lauroyl group. Preliminary structure‐activity relationship points that unprotected OH group at C‐1 and C‐2 is not necessary to the antiparasitic activity and none derivative was less active than lycorine. The lycorine structural requisites required to kill this amitochondriate cell seem to be different in comparison to the derivatives most active against other parasites and tumor cell lines, both mitochondriated cells. This result is an important contribution with ...

Evaluation of Seeplex® STD6 ACE Detection kit for the diagnosis of six bacterial sexually transmitted infections
Wed, 18 Jan 2012 06:51:44 +0100 | Journal of Infection and Chemotherapy
Abstract  Traditionally, the diagnosis of bacterial sexually transmitted infection (STI) has been dependent on the isolation of the causative pathogens by culturing endocervical or urethral swab specimens on selective media. While such procedures typically provide excellent diagnostic accuracy, they are often time-consuming and expensive. A multiplex polymerase chain reaction (PCR) assay, based on a semi-automated detection system, was evaluated for the detection of six STI causative organisms. The Seeplex® STD6 ACE (auto-capillary electrophoresis) Detection assay employed six pairs of dual priming oligonucleotide (DPO™) primers specifically targeted to unique genes of Chlamydia trachomatis, Neisseria gonorrhoeae, Mycoplasma genitalium, Ureaplasma urealyticum, Mycoplasma ...

The N-glycans of Trichomonas vaginalis contain variable core and antennal modifications
Wed, 11 Jan 2012 05:00:00 +0100 | Glycobiology
In this study, we present both mass spectrometric and high-performance liquid chromatography data about the N-glycans of different strains of Trichomonas vaginalis, a parasite of the human reproductive tract. The major structure in all strains examined is a truncated oligomannose form (Man5GlcNAc2) with α1,2-mannose residues, compatible with a previous bioinformatic examination of the glycogenomic potential of T. vaginalis. In addition, dependent on the strain, N-glycans modified by pentose residues, phosphate or phosphoethanolamine and terminal N-acetyllactosamine (Galβ1,4GlcNAc) units were found. The modification of N-glycans by N-acetyllactosamine in at least some strains is shared with the lipo(phospho)glycan and may represent a further interaction partner for host galectins...

Real-time PCR improve detection of Trichomonas vaginalis compared to conventional techniques
Mon, 09 Jan 2012 06:32:48 +0100 | Comparative Clinical Pathology
Abstract   Trichomonas vaginalis is the cause of one of the most common types of vaginitis, trichomoniasis. Clinical manifestations of symptomatic women are generally nonspecific, but include vaginal discharge, vaginitis and irritation. T. vaginalis infection has also been linked to the increased risk of human immunodeficiency virus transmission. The aim of the study was to compare a real-time polymerase chain reaction (PCR) assay with culture and wet-mount examination for the detection of T. vaginalis. This is a descriptive analytical study. Vaginal swabs from 504 female patients with suspected vaginitis were included in the study. They were subjected to culture, wet-mount microscopic examination (WM), and real-time PCR. Real-time fluorescence resonance energy transfer hybr...

Leukotriene B4 receptors BLT1 and BLT2 are involved in interleukin-8 production in human neutrophils induced by Trichomonas vaginalis-derived secretory products
Wed, 04 Jan 2012 06:59:53 +0100 | Inflammation Research
Conclusion  Our results suggest that LTB4 receptors BLT1 and BLT2 are involved in IL-8 production in neutrophils induced by T. vaginalis. Content Type Journal ArticleCategory Short CommunicationPages 1-6DOI 10.1007/s00011-011-0425-3Authors Young Hee Nam, Department of Environmental Medical Biology and Institute of Tropical Medicine, Yonsei University College of Medicine, 134 Sichon-dong, Seodaemun-gu, Seoul, 120-752 KoreaArim Min, Department of Environmental Medical Biology and Institute of Tropical Medicine, Yonsei University College of Medicine, 134 Sichon-dong, Seodaemun-gu, Seoul, 120-752 KoreaSeong Hoon Kim, Department of Environmental Medical Biology and Institute of Tropical Medicine, Yonsei University College of Medicine, 134 Sichon-dong, Seodaemun-gu, Seoul, 1...

Potentiating Metronidazole Scaffold against Resistant Trichomonas: Design, Synthesis, Biology and 3D–QSAR Analysis
Wed, 28 Dec 2011 18:53:39 +0100 | ACS Medicinal Chemistry Letters
ACS Medicinal Chemistry LettersDOI: 10.1021/ml200161t (Source: ACS Medicinal Chemistry Letters)

Structure of the Trichomonas vaginalis Myb3 DNA-binding domain bound to a promoter sequence reveals a unique C-terminal {beta}-hairpin conformation
Sun, 25 Dec 2011 05:00:00 +0100 | Nucleic Acids Research
Trichomonas vaginalis Myb3 transcription factor (tvMyb3) recognizes the MRE-1 promoter sequence and regulates ap65-1 gene, which encodes a hydrogenosomal malic enzyme that may play a role in the cytoadherence of the parasite. Here, we identified tvMyb353–180 as the essential fragment for DNA recognition and report the crystal structure of tvMyb353–180 bound to MRE-1 DNA. The N-terminal fragment adopts the classical conformation of an Myb DNA-binding domain, with the third helices of R2 and R3 motifs intercalating in the major groove of DNA. The C-terminal extension forms a β-hairpin followed by a flexible tail, which is stabilized by several interactions with the R3 motif and is not observed in other Myb proteins. Interestingly, this unique C-terminal fragment does not sta...