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Roche in 2011: Strong results and positive outlook
Wed, 01 Feb 2012 12:23:22 +0100 | Drugs.com - Pharma News
Group sales rise 2% 1 (-10% in Swiss francs; +6% in US dollars), excluding Tamiflu. Significant foreign exchange impact of –12 percentage points due to appreciation of the Swiss franc; overall Group sales at 42.5 billion Swiss... (Source: Drugs.com - Pharma News)

Review raises questions about why government stockpiling zanamivir, oseltamivir
Tue, 31 Jan 2012 05:00:00 +0100 | Drug Topics - Top News
Zanamivir and oseltamivir (Tamiflu, Roche) can help prevent and treat the symptoms of influenza, but there is not enough information to evaluate the drugs’ safety and efficacy for preventing the spread of flu or pneumonia, according to a new review published online January 18. (Source: Drug Topics - Top News)

Neuraminidase inhibitors for preventing and treating influenza in healthy adults and children
Tue, 31 Jan 2012 05:00:00 +0100 | NeLM - Drug Class Focused Reviews
Source: Cochrane Library Area: Evidence > Drug Class Focused Reviews Background Planning for outbreaks of influenza is a high priority public health issue for national governments. Neuraminidase inhibitors (NIs) are thought to help reduce the symptoms of influenza with several possible mechanisms proposed. NIs have been stockpiled with a view to their widespread use in the event of a pandemic. However, the evidence base for this class of agents remains a source of debate. In a previous review we have documented substantial risks of publication bias of trials of NIs for influenza (60% of patient data from phase III treatment trials of oseltamivir have never been published) and reporting bias in the published trials. Our confidence in the conclusions of previous versions of this rev...

Review raises questions about why government stockpiling zanamivir, oseltamivir
Tue, 31 Jan 2012 05:00:00 +0100 | Modern Medicine
Zanamivir and oseltamivir (Tamiflu, Roche) can help prevent and treat the symptoms of influenza, but there is not enough information to evaluate the drugs’ safety and efficacy for preventing the spread of flu or pneumonia, according to a new review published online January 18. (Source: Modern Medicine)

Synthesis and preliminary biological evaluation of 5�substituted�2�(4�substituted phenyl)�1,3�benzoxazoles as a novel class of influenza virus A inhibitors
Fri, 27 Jan 2012 05:00:00 +0100 | Chemical Biology and Drug Design
The diversity�oriented chemistry synthesis together with the random screening approach has permitted the discovery and optimization of novel antiviral lead compounds. In this paper, a series of novel 5�substituted�2�(4�substituted phenyl)�1,3�benzoxazoles was synthesized and evaluated for their in vitro anti�influenza A virus (IFV�A) and anti�influenza B virus (IFV�B) activity. The activity was monitored by the MTS assay in the Madin�Darby canine kidney (MDCK) cells. Compound 7h showed excellent inhibitory activity and selective index against A/H3N2 (EC50 = 37.03 μM, SI>5), which were all higher than that of the reference drug Oseltamivir (EC50 >59.00 μM, SI>1). However, no compound displays inhibitory activity against influenza B virus.© 2012 John Wiley...

Neuraminidase inhibitors for preventing and treating influenza in healthy adults and children.
Thu, 26 Jan 2012 08:18:08 +0100 | Cochrane Database of Systematic Reviews
CONCLUSIONS: We found a high risk of publication and reporting biases in the trial programme of oseltamivir. Sub-population analyses of the influenza infected population in the oseltamivir trial programme are not possible because the two arms are non-comparable due to oseltamivir's apparent interference with antibody production. The evidence supports a direct oseltamivir mechanism of action on symptoms but we are unable to draw conclusions about its effect on complications or transmission. We expect full clinical study reports containing study protocol, reporting analysis plan, statistical analysis plan and individual patient data to clarify outstanding issues. These full clinical study reports are at present unavailable to us. PMID: 22258996 [PubMed - in process] (Source: Cochrane Dat...

Neuraminidase inhibitors for preventing and treating influenza in children.
Thu, 26 Jan 2012 08:18:08 +0100 | Cochrane Database of Systematic Reviews
CONCLUSIONS: Oseltamivir and zanamivir appear to have modest benefit in reducing duration of illness in children with influenza. However, our analysis was limited by small sample sizes and an inability to pool data from different studies. Oseltamivir reduces the incidence of acute otitis media in children aged one to five years but is associated with a significantly increased risk of vomiting. One study demonstrated that laninamivir octanoate was more effective than oseltamivir in shortening duration of illness in children with oseltamivir-resistant influenza A/H1N1. The benefit of oseltamivir and zanamivir in preventing the transmission of influenza in households is modest and based on weak evidence. However, the clinical efficacy of neuraminidase inhibitors in 'at risk' children is still...

Stockpiled Tamiflu Has 'Modest' Benefits: ReportsStockpiled Tamiflu Has 'Modest' Benefits: Reports
Wed, 25 Jan 2012 01:06:57 +0100 | Medscape Medical News Headlines
After billions of dollars worldwide have been spent stockpiling the anti-flu drug Tamiflu (oseltamivir), two new reports cast doubt on the medication's benefits. Reuters Health Information (Source: Medscape Medical News Headlines)

Stockpiled flu drug has "modest" benefits: reports
Mon, 23 Jan 2012 20:13:27 +0100 | Reuters: Health
NEW YORK (Reuters Health) - After billions of dollars worldwide have been spent stockpiling the anti-flu drug Tamiflu, two new reports cast doubt on the medication's benefits and say its side effects may have been underestimated. (Source: Reuters: Health)