Thu May 17 21:11:06 SGT 2012  
SHIM CLINIC
MEN'S CLINIC SINGAPORE™
168 Bedok South Avenue 3 #01-473
Singapore 460168
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Hypogonadism | Shim Clinic, MEN'S CLINIC SINGAPORE™

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Summary

Hypogonadism | Shim Clinic, MEN'S CLINIC SINGAPORE™: Andropause test, treatment by Testosterone Replacement Therapy (TRT) with Nebido® injection, Andriol® oral capsules, or AndroGel® topical therapy clinic, Singapore. Private and confidential service. Definitions, references, and latest news.

Description

Hypogonadism in the male refers to the decrease in the functional activity of the male gonads (testis), resulting in a testosterone level falling below the normal range for a given age.
  • Primary hypogonadism, or hypergonadotropic hypogonadism (high LH and/or FSH), or primary testicular failure. Eg: Klinefelters syndrome.
  • Secondary hypogonadism, or hypogonadotropic hypogonadism (low LH and/or FSH), due to a defect in the hypothalamus or the pituitary.

Andropause is the male equivalent of female menopause. Menopause in a woman literally means the end of monthly cycles. As this does not occur in a male, it refers to the stage of life when symptoms of aging appear in men. Also called Late-onset hypogonadism (LOH), and previously referred to as androgen deficiency in aging males (ADAM) It is an age related decline of testosterone, one of the causes of secondary hypogonadism

Table 1. Questions Used as Part of the Saint Louis University ADAM Questionnaire
  1. Do you have a decrease in libido (sex drive)?
  2. Do you have a lack of energy?
  3. Do you have a decrease in strength and/or endurance?
  4. Have you lost height?
  5. Have you noticed a decreased "enjoyment of life"?
  6. Are you sad and/or grumpy?
  7. Are your erections less strong?
  8. Have you noted a recent deterioration in your ability to play sports?
  9. Are you falling asleep after dinner?
  10. Has there been a recent deterioration in your work performance?

NOTE. A positive questionnaire result is defined as a "yes" answer to questions 1 or 7 or any 3 other questions.
Yes / No
 

Reference

Morley JE, Charlton E, Patrick P, Kaiser FE, Cadeau P, McCready D, Perry HM 3rd. Validation of a Screening Questionnaire for Androgen Deficiency in Aging Males Metabolism. 2000 Sep;49(9):1239-42.

Testosterone deficiency syndrome (TDS) refers to the clinical signs and symptoms that result from an abnormally low testosterone level, caused by hypogonadism.

Testosterone test and testosterone replacement therapy (TRT) with a testosterone preparation:

TimeInvestigationTreatment
Before Week 0 Testosterone Essential:
  • Prostate Specific Antigen (PSA)
    • If > 4ng/ml, check for prostate Ca
  • Haematocrit (Hct)
    • If > 55%, stop TRT till Hct drops to safe level.
Recommended:
  • Liver Function Test (LFT)
  • Fasting lipids
Optional:
  • FSH
  • LH
Week 0 Nebido® #1
Week 6 Nebido® #2
3 month
(week 12)
Essential:
  • Prostate Specific Antigen (PSA)
  • Haematocrit (Hct)
Week 18 Nebido® #3
Before Nebido® #4
(Week 27)
Testosterone
  • If 10-15 nmol/L - maintain interval at 12 weeks
  • If < 10 nmol/L - decrease interval to 10 weeks
  • If > 15 nmol/L - increase interval to 14 weeks
Week 30 Nebido® #4
9 month
(week 36)
Essential:
  • Prostate Specific Antigen (PSA)
  • Haematocrit (Hct)
Annually Testosterone

Essential:

  • Prostate Specific Antigen (PSA)
  • Haematocrit (Hct)
Recommended:
  • Liver Function Test (LFT)
  • Fasting lipids

Men's health issues:

References
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