HPV Singapore Clinic

HPV Singapore Clinic: Human papillomavirus (HPV) - symptoms in men/women, screening/diagnosis, testing/check, treatment clinic, Singapore - Private and confidential service. Definitions, references, and latest news.

Description

Table of Contents

• HPV (human papillomavirus)
• Genital warts
  • Genital warts treatment
• Cervical cancer
  • Cervical cancer vaccine
• HPV vaccine
  • Gardasil®
  • Cervarix®

• 100% of genital warts
• 100% of cervical cancers in females,
• 90% of anal cancers in males & females
• 40% of external genitalia cancers
  • penile cancers in males,
  • vulvar cancers in females,
  • vaginal cancers in females,
• 12% of oropharyngeal cancers (mouth and throat cancers)
• 3% of oral cancers

• HPV types 1 and 2 cause plantar warts
• HPV types 3 and 10 cause flat warts
• HPV types 6 and 11 (preventable with Gardasil® vaccination) cause 90% of genital warts
• HPV types 16 and 18 (preventable with Gardasil® or Cervarix® vaccination) cause 70% of cervical cancers in females
• HPV types 16, 18, 31, 33, 45, 52, and 58 (preventable with nine-valent vaccination) cause 90% of cervical cancers in females. It may be available by 2013.

• QIAGEN - digene HC2 High-Risk HPV DNA Test - For detection of human papillomavirus infections using hybrid capture 2 technology
  • Detects 13 high-risk HPV types: 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, and 68.
  • Unable to differentiate which types are positive.
  • Cost is SG$200/=
• QIAGEN - digene HC2 HPV DNA Test - For detection of human papillomavirus infections
  • Detects 13 high-risk HPV types: 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, and 68. And 5 low-risk types: 6, 11, 42, 43, and 44.
  • Unable to differentiate which types are positive.
  • Not available in Singapore. Unlikely to be available in future.
• Hybribio® Real Time PCR HPV Detection Kit
  • Detects 13 high-risk HPV types: 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, and 68.
  • Able to differentiate which types are positive.
  • Will be available in Singapore soon.

Genital HPV types, disease caused, vaccine & test coverage:

Genital warts is also known as condyloma, condylomata acuminata, venereal wart, anal wart, anogenital wart, and "cauliflower" sex disease.

Genital warts appear within 3 months after sexual contact with an infected person.

Genital warts:

• are usually soft, pink cauliflower-like growths or flesh-coloured bumps on the sex organs
• may also be hard and smooth
• occur alone or in groups
• tend to recur after treatment
• increase the risk of cervical cancer in women.

A person with genital warts can infect others through sexual contact.

Genital warts treatment is usually by cryosurgery with liquid nitrogen.

Prevention is possible with a HPV vaccine like Gardasil®, which covers types 6 and 11, as they cause 90% of genital warts.

Cervical cancer is caused by HPV (human papillomavirus).

• 70% of cervical cancers is caused by HPV types 16 & 18. Which may be prevented by vaccination with Gardasil® or Cervarix®.
• 90% cervical cancers is caused by HPV types 6, 11, 16, 18, 31, 33, 45, 52, and 58. Which may be prevented by vaccination with nine-valent. It may be available by 2013.

• Gardasil® [HPV (Human Papillomavirus) Quadrivalent (Types 6, 11, 16, and 18) Vaccine, Recombinant]
• Cervarix® [HPV (Human Papillomavirus) Bivalent (Types 16 and 18) Vaccine, Recombinant]
• nine-valent [HPV (Human Papillomavirus) Nonavalent (Types 6, 11, 16, 18, 31, 33, 45, 52, and 58) Vaccine, Recombinant] - to be released in 2013

• 2006 June 8th - US FDA approves use in females aged 9 to 26 years
• 2006 - Singapore HSA approval
• 2009 January 9th - Merck applying for use in females aged 27 to 45 years
• 2009 October 16th - US FDA approves use in males aged 9 to 26 years
• If this trend continues, we would likely see it being approved for used in males aged 27 to 45 years.
• Check our vaccines page for the price, doses required and dose sechedule.

• 2007 - Singapore HSA approval
• 2009 October 16th - US FDA approves use in females aged 10 to 25 years

References

• Hpv - Wikipedia, the free encyclopedia
• Hpv: Definition from Answers.com
• Hpv - definition of Hpv in the Medical dictionary - by the Free Online Medical Dictionary, Thesaurus and Encyclopedia.
• WHO | Human papillomavirus (HPV)
• WHO | Human papillomavirus and HPV vaccines
• CDC - Human Papillomavirus (HPV)

Influences on Human Papillomavirus Vaccination Status Among Female College Students
Fri, 03 Sep 2010 22:13:25 +0100 | Journal of Women
Journal of Women's Health , Vol. 0, No. 0. (Source: Journal of Women)

Molecular Diagnostics of Human Papillomavirus
Fri, 03 Sep 2010 20:49:10 +0100 | Medscape Infectious Diseases Headlines
This review summarizes the molecular testing methods currently in use for the detection and genotyping of human papillomavirus (HPV). What's in store for the future? Laboratory Medicine (Source: Medscape Infectious Diseases Headlines)

The Cancer-Causing Sex Virus
Fri, 03 Sep 2010 19:00:00 +0100 | Forbes.com Health News
HPV, known for causing cervical cancer, is emerging as the leading cause of throat cancer in men. (Source: Forbes.com Health News)

Human Papillomavirus DNA Testing for Cervical Cancer Screening: Practical Aspects in Developing Countries
Fri, 03 Sep 2010 07:25:28 +0100 | Molecular Diagnosis
(Source: Molecular Diagnosis)

Development of Genital Warts after Incident Detection of Human Papillomavirus Infection in Young Men
Thu, 02 Sep 2010 20:20:13 +0100 | The Journal of Infectious Diseases Latest Issue
The Journal of Infectious Diseases, Volume 0, Issue 0, Page 000, Latest Articles. Determining the rate at which men develop genital warts after infection with alpha genus human papillomavirus (HPV) types will provide important information for the design of prevention strategies. We conducted a cohort study of 18–21‐year‐old men who underwent triannual genital examinations. The 24‐month cumulative genital wart incidence was 57.9% (95% confidence interval [CI], 38.1%–79.1%) among 46 men with incident detection of HPV‐6 or HPV‐11 infection, 2.0% (95% CI, 0.5%–7.9%) among 161 men with incident detection of infection with other HPV types, and 0.7% (95% CI, 0.2%–2.8%) among 331 men who tested negative for HPV. Our results suggest that genital warts are common after HPV‐...

Safety and Immunogenicity of the Quadrivalent Human Papillomavirus Vaccine in HIV‐1–Infected Men
Thu, 02 Sep 2010 20:19:57 +0100 | The Journal of Infectious Diseases Latest Issue
Conclusions. The quadrivalent HPV vaccine appears safe and highly immunogenic in HIV‐1–infected men. Efficacy studies in HIV‐1–infected men are warranted. Clinical trials registration. NCT 00513526. (Source: The Journal of Infectious Diseases Latest Issue)

Prevalence of human papillomavirus genotypes in northern Taiwanese women
Thu, 02 Sep 2010 09:27:58 +0100 | Journal of Medical Virology
Abstract (Source: Journal of Medical Virology)

Prevalence and genotype distribution of cervical human papillomavirus infection in Macao
Thu, 02 Sep 2010 09:27:57 +0100 | Journal of Medical Virology
Abstract (Source: Journal of Medical Virology)

Human papillomavirus and colorectal cancer: evidences and pitfalls of published literature
Thu, 02 Sep 2010 06:23:57 +0100 | International Journal of Colorectal Disease
Conclusions  HPV has been detected in the majority of reported series, but published literature lacks in definitive data regarding standard methods of investigation and stratification of groups and population. These data encourage further studies with the aim to investigate the presence of the virus in larger series, its possible role in oncogenesis, the integration in host genome, the expression of viral oncoproteins, the mutations in HPV positive cancers and routes of colon infection (hematologic/lymphatic spreading or perineal diffusion). Content Type Journal ArticleDOI 10.1007/s00384-010-1049-8Authors Laura Lorenzon, II Faculty of Medicine and Surgery, University of Rome “La Sapienza”, St. Andrea Hospital, Via di Grottarossa, 1035-39, 00189 Rome, ItalyMario...