HPV | Shim Clinic, STD CLINIC SINGAPORE™

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Summary

HPV | Shim Clinic, STD CLINIC SINGAPORE™: Human papillomavirus (HPV) - symptoms in men/women, screening/diagnosis, testing/check, treatment clinic, Singapore - Private and confidential service. Definitions, references, and latest news.

Description

Table of Contents

• HPV (human papillomavirus)
• Genital warts
  • Genital Warts Treatment
• Cervical Cancer
  • Cervical Cancer Vaccine
• HPV vaccine
  • Gardasil®
  • Cervarix®
  • V503
• HPV test

• 100% of genital warts
• 100% of cervical cancers in females,
• 90% of anal cancers in males & females
• 40% of external genitalia cancers
  • penile cancers in males,
  • vulvar cancers in females,
  • vaginal cancers in females,
• 12% of oropharyngeal cancers (mouth and throat cancers)
• 3% of oral cancers

• HPV types 1 and 2 cause plantar warts
• HPV types 3 and 10 cause flat warts
• HPV types 6 and 11 (preventable with Gardasil® vaccination) cause 90% of genital warts
• HPV types 16 and 18 (preventable with Gardasil® or Cervarix® vaccination) cause 70% of cervical cancers in females
• HPV types 16, 18, 31, 33, 45, 52, and 58 (preventable with V503 vaccination) cause 90% of cervical cancers in females. It may be available by 2013.

Genital warts is also known as condyloma, condylomata acuminata, venereal wart, anal wart, anogenital wart, and "cauliflower" sex disease.

Genital warts appear within 3 months after sexual contact with an infected person.

Genital warts:

• are usually soft, pink cauliflower-like growths or flesh-coloured bumps on the sex organs
• may also be hard and smooth
• occur alone or in groups
• tend to recur after treatment
• increase the risk of cervical cancer in women.

A person with genital warts can infect others through sexual contact.

Genital warts treatment is usually by cryosurgery with liquid nitrogen. Genital warts removal may also be done by curettage.

Prevention is possible with a HPV vaccine like Gardasil®, which covers types 6 and 11, as they cause 90% of genital warts.

Cervical cancer

• 100% of cervical cancers is caused by HPV (human papillomavirus).
• 70% of cervical cancers is caused by HPV types 16 & 18. Which may be prevented by vaccination with Gardasil® or Cervarix®.
• 90% cervical cancers is caused by HPV types 16, 18, 31, 33, 45, 52, and 58. Which may be prevented by vaccination with V503. It may be available by 2013.

• Gardasil® [HPV (Human Papillomavirus) Quadrivalent (Types 6, 11, 16, and 18) Vaccine, Recombinant]
• Cervarix® [HPV (Human Papillomavirus) Bivalent (Types 16 and 18) Vaccine, Recombinant]
• V503 [HPV (Human Papillomavirus) Nonavalent (Types 6, 11, 16, 18, 31, 33, 45, 52, and 58) Vaccine, Recombinant]

• 2006 June 8th - US FDA approves use in females aged 9 to 26 years
• 2006 - Singapore HSA approval
• 2008 September 12th - US FDA approves use to prevent vulvar and vaginal cancer
• 2009 October 16th - US FDA approves use to prevent genital warts in males aged 9 to 26 years
• 2010 December 22nd - US FDA approves use to prevent anal cancer in males and females aged 9 to 26 years
• 2010 December 22nd - Singapore HSA approves use to prevent genital warts in males aged 9 to 26 years
• 2011 April 5th - US FDA approves use in women 27 through 45 years of age

• 2007 - Singapore HSA approval
• 2009 October 16th - US FDA approves use in females aged 10 to 25 years
• 2011 July 19th - US FDA approves use in females as young as 9 years of age
• 2011 August 3rd - Singapore HSA approves use for the prevention of persistent infection, premalignant cervical lesions and cervical cancer

• 2007 October 12th - Broad Spectrum HPV (Human Papillomavirus) Vaccine Study in 16-to 26-Year-Old Women (V503-001)
• 2009 July 21st - A Study of V503 in Preadolescents and Adolescents (V503-002)
• 2010 May 11th - The Phase III trial is ongoing and Merck anticipates filing a Biologics License Application (BLA) in 2012
• 2010 July - Merck is recruiting for Phase III clinical trials of a nine-valent vaccine

Vaccine	Against	Disease	Doses req'd	Dose schedule	Price per dose (SG$)
Hepatitis A vaccine	Hepatitis A virus	Hepatitis A	2	mo. 0 & 6	$90/=
Hepatitis B vaccine	Hepatitis B virus	Hepatitis B	3-4	mo. 0, 1, & 6 or mo. 0, 1, 2, & 12 or d. 0, 7, 21 & mo. 12	$50/=
Twinrix®	Hepatitis A virus Hepatitis B virus	Hepatitis A Hepatitis B	3-4	mo. 0, 1, & 6 or d. 0, 7, 21 & mo. 12	$120/=
Gardasil® - HPV vaccine	HPV types 6, 11, 16 and 18	Genital warts Cervical cancer	3	mo. 0, 2, & 6 or mo. 0, 1, & 4	$195/=
Cervarix® - HPV vaccine	HPV types 16 and 18 (31, 33, and 45)	Genital warts Cervical cancer	3	mo. 0, 1, & 6	$195/=
V503 - HPV vaccine	HPV types 6, 11, 16, 18, 31, 33, 45, 52, and 58	Genital warts Cervical cancer	3	mo. 0, 2, & 6 or mo. 0, 1, & 4	$???/=

References

• TWINRIX.com

HPV test for men/women.

• Digene® High-Risk HPV DNA Test
  • QIAGEN - digene HC2 High-Risk HPV DNA Test - For detection of human papillomavirus infections using hybrid capture 2 technology
  • Detects 13 high-risk HPV types: 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, and 68.
  • Unable to differentiate which types are positive.
  • Cost is SG$200/=
• Digene® HPV DNA Test
  • QIAGEN - digene HC2 HPV DNA Test - For detection of human papillomavirus infections
  • Detects 13 high-risk HPV types: 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, and 68. And 5 low-risk types: 6, 11, 42, 43, and 44.
  • Unable to differentiate which types are positive.
  • Not available in Singapore. Unlikely to be available in future.
• Hybribio®
  • HPV GenoArray Test Kit
  • Detects 15 high-risk HPV types: 16, 18, 31, 33, 35, 39, 45, 51, 52, 53, 56, 58, 59, 66, and 68. And 6 low-risk HPV types: 6, 11, 42, 43, 44, CP8304
  • Able to differentiate which types are positive.
  • May be available in Singapore soon.
• Cobas® 4800 HPV Test
  • Cobas® 4800 HPV Test
  • Detects 14 high-risk HPV types: 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 66, and 68
  • The test specifically identifies (types) HPV 16 and HPV 18, while concurrently detecting the rest of the high risk types (31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 66, and 68)
  • Cost is SG$200/=

References

• HPV - Wikipedia, the free encyclopedia
• HPV: Definition from Answers.com
• HPV - definition of HPV in the Medical dictionary - by the Free Online Medical Dictionary, Thesaurus and Encyclopedia.
• WHO | Human papillomavirus (HPV)
• WHO | Human papillomavirus and HPV vaccines
• CDC - Human Papillomavirus (HPV)
• Human_papillomavirus | 2can Support Portal | EBI

US Pediatricians Recommend Routine HPV Vaccination For Boys
Fri, 03 Feb 2012 20:00:00 +0100 | Health News from Medical News Today
As part of a revised standard published this week, the American Academy of Pediatrics says boys should be routinely vaccinated against the human papillomavirus (HPV), a common virus that is spread through sexual contact. Although there are dozens of types of HPV, vaccines can protect both male and females against some of the more common types that can lead to disease and cancer... (Source: Health News from Medical News Today)

HPV vaccine now recommended for all boys, CDC says
Fri, 03 Feb 2012 19:18:30 +0100 | Health News: CBSNews.com
At least 50 percent of sexually active men and women get will get infected with human papillomavirus at some point, according to CDC (Source: Health News: CBSNews.com)

Well: HPV Vaccine Now Recommended for Boys, Hepatitis B Vaccine for Diabetes
Fri, 03 Feb 2012 03:29:32 +0100 | NYT Health
Federal health officials recommended this week that all boys be routinely vaccinated against human papillomavirus, or HPV, and that people with diabetes be vaccinated against hepatitis B. (Source: NYT Health)

National Briefing | Health: Officials Recommend the HPV Vaccine for All Boys
Fri, 03 Feb 2012 01:10:05 +0100 | NYT Health
Federal health officials recommended on Thursday that all boys be routinely vaccinated against infection with human papillomavirus, or HPV. (Source: NYT Health)

Human papillomavirus detected in esophageal squamous cell carcinoma in Iran.
Fri, 03 Feb 2012 00:25:02 +0100 | European Journal of Internal Medicine
CONCLUSION: In conclusion, the present study showed that a small proportion of ESCC specimens from Iran harbor HPV16, 18 genome using a highly sensitive method. As different rates have been reported from Iran, a more widespread study with more precise definition of geographical differences could delineate the potential involvement of HPV in the development of ESCC in Iranian population. PMID: 22284258 [PubMed - in process] (Source: European Journal of Internal Medicine)

Well Blog: HPV Vaccine Now Recommended for Boys, Hepatitis B Vaccine for Diabetes
Thu, 02 Feb 2012 16:59:25 +0100 | NYT Health
Federal health officials recommended this week that all boys be routinely vaccinated against human papillomavirus, or HPV, and that people with diabetes be vaccinated against hepatitis B. (Source: NYT Health)

HPV vaccines (Gardasil) now pushed onto boys in Canada
Thu, 02 Feb 2012 06:00:00 +0100 | NaturalNews.com
There is still a whole lot of money to be made from pushing human papillomavirus (HPV) vaccines on young people around the world. But in order to accomplish this, the market for the vaccines, which include Merck & Co.'s Gardasil and GlaxoSmithKline's Cervarix, must be... (Source: NaturalNews.com)

HPV vaccine recommended for boys
Thu, 02 Feb 2012 05:00:00 +0100 | Health Facts and Fears
Both the Centers for Disease Control and Prevention and the American Academy of Pediatrics are now advising parents to vaccinate their boys against the human papillomavirus (HPV), especially before they become sexually active. (Source: Health Facts and Fears)

Oral HPV infection linked with sexual behavior
Thu, 02 Feb 2012 00:00:00 +0100 | MedWire News - Oncology
Detailed information on the epidemiology of oral human papillomavirus infection in the United States has been published, showing that the prevalence is around 7% in the general population, but as high as 45% in certain high-risk subgroups. (Source: MedWire News - Oncology)