HPV Vaccine | Shim Clinic, Singapore | HIV STD TESTING TREATMENT™

HPV Vaccine | Shim Clinic, Singapore | HIV STD TESTING TREATMENT™: Human papillomavirus (HPV) vaccine jab/shot/injection schedule, to vaccinate against the HPV, to immunise against cervical/penile/anal/mouth/throat cancer and genital warts clinic, Singapore. Private and confidential service. Definitions, references, and latest news.

Description

Table of Contents

• HPV (human papillomavirus)
• HPV Symptoms / Genital warts
• Cervical Cancer
• HPV Screen / HPV Screening / HPV Test / HPV Testing / HPV Check / HPV Checking
  • Digene®
• HPV Treatment / Genital Warts Treatment / Genital Warts Removal
• HPV vaccine / Cervical Cancer Vaccine
  • Gardasil®
  • Cervarix®
  • V503

HPV vaccine (previously known as cervical cancer vaccine) types:

• Gardasil® [HPV (Human Papillomavirus) Quadrivalent (Types 6, 11, 16, and 18) Vaccine, Recombinant]
• Cervarix® [HPV (Human Papillomavirus) Bivalent (Types 16 and 18) Vaccine, Recombinant]
• V503 [HPV (Human Papillomavirus) Nonavalent (Types 6, 11, 16, 18, 31, 33, 45, 52, and 58) Vaccine, Recombinant]

• PROFESSIONAL O&G GUIDELINES ON HPV VACCINATION IN SINGAPORE

• 2006 June 8th - US FDA approves use in females aged 9 to 26 years
• 2006 - Singapore HSA approval
• 2008 September 12th - US FDA approves use to prevent vulvar and vaginal cancer
• 2009 October 16th - US FDA approves use to prevent genital warts in males aged 9 to 26 years
• 2010 December 22nd - US FDA approves use to prevent anal cancer in males and females aged 9 to 26 years
• 2010 December 22nd - Singapore HSA approves use to prevent genital warts in males aged 9 to 26 years
• 2011 April 5th - US FDA approves use in women 27 through 45 years of age
• 2011 December 20th Singapore HSA approves use to prevent anal cancer in males and females aged 9 to 26 years

• Gardasil.com
• Gardasil® @ US FDA

• 2007 - Singapore HSA approval
• 2009 October 16th - US FDA approves use in females aged 10 to 25 years
• 2011 July 19th - US FDA approves use in females as young as 9 years of age
• 2011 August 3rd - Singapore HSA approves use for the prevention of persistent infection, premalignant cervical lesions and cervical cancer

• Cervarix.com
• Cervarix® @ US FDA

• 2007 October 12th - Broad Spectrum HPV (Human Papillomavirus) Vaccine Study in 16-to 26-Year-Old Women (V503-001)
• 2009 July 21st - A Study of V503 in Preadolescents and Adolescents (V503-002)
• 2010 May 11th - The Phase III trial is ongoing and Merck anticipates filing a Biologics License Application (BLA) in 2012
• 2010 July - Merck is recruiting for Phase III clinical trials of a nine-valent vaccine

HPV test for men/women.

• Digene® High-Risk HPV DNA Test
  • QIAGEN - digene HC2 High-Risk HPV DNA Test - For detection of human papillomavirus infections using Hybrid Capture 2 technology
  • Detects 13 high-risk HPV types: 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, and 68.
  • Unable to differentiate which types are positive.
  • Cost is SG$200/=
• Digene® HPV DNA Test
  • QIAGEN - digene HC2 HPV DNA Test - For detection of human papillomavirus infections
  • Detects 13 high-risk HPV types: 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, and 68. And 5 low-risk types: 6, 11, 42, 43, and 44.
  • Unable to differentiate which types are positive.
  • Not available in Singapore. Unlikely to be available in the future.
• Digene® HPV Genotyping PS Test
  • QIAGEN - Researchers Say Identification of Women with HPV Types 16, 18 and 45 Could Improve Early Intervention to Stop Cervical Cancer
  • Specifically identifies the presence of types 16, 18 and 45.
  • If the High-Risk HPV DNA Test is positive, then the Genotyping PS Test is done free of charge.
• Hybribio®
  • HPV GenoArray Test Kit
  • Detects 15 high-risk HPV types: 16, 18, 31, 33, 35, 39, 45, 51, 52, 53, 56, 58, 59, 66, and 68. And 6 low-risk HPV types: 6, 11, 42, 43, 44, CP8304
  • Able to differentiate which types are positive.
  • May be available in Singapore soon.
• Cobas® HPV Test
  • Cobas® HPV Test
  • Detects 14 high-risk HPV types: 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 66, and 68
  • The test specifically identifies (types) HPV 16 and HPV 18, while concurrently detecting the rest of the high risk types (31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 66, and 68)
  • Cost is SG$200/=
• LINEAR ARRAY® HPV Genotyping Test
  • LINEAR ARRAY® HPV Genotyping Test
  • Identifies 37 high-risk HPV genotypes 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 66, 68, 73 (MM9), 82 (MM4) low-risk HPV genotypes 6, 11, 26, 40, 42, 53, 54, 55, 61, 62, 64, 67, 69, 70, 71, 72, 81, 83 (MM7), 84 (MM8), IS39, and CP6108
• INNO-LiPA HPV Genotyping Extra
  • INNO-LiPA HPV Genotyping Extra
  • Identifies 15 high-risk HPV genotypes (16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 68, 73, 82) 3 probable high-risk HPV genotypes (26, 53, 66) 7 low-risk HPV genotypes (6, 11, 40, 43, 44, 54, 70) and some additional types (69, 71, 74).
• PapilloCheck®
  • PapilloCheck®
  • Identifies 24 hiv-risk HPV types 16 18 31 33 35 39 45 51 52 53 56 58 59 66 68 70 73 82 and low-risk HPV types 6 11 40 42 43 44

HPV / human papillomavirus. There are nearly 200 known types of HPV. They cause

• 100% of genital warts
• 100% of cervical cancers in females,
• 90% of anal cancers in males & females
• 40% of external genitalia cancers
  • penile cancers in males,
  • vulvar cancers in females,
  • vaginal cancers in females,
• 12% of oropharyngeal cancers (mouth and throat cancers)
• 3% of oral cancers

• HPV types 1 and 2 cause plantar warts
• HPV types 3 and 10 cause flat warts
• HPV types 6 and 11 (preventable with Gardasil® vaccination) cause 90% of genital warts
• HPV types 16 and 18 (preventable with Gardasil® or Cervarix® vaccination) cause 70% of cervical cancers in females
• HPV types 16, 18, 31, 33, 45, 52, and 58 (preventable with V503 vaccination) cause 90% of cervical cancers in females. It may be available by 2013.

• Human_papillomavirus | 2can Support Portal | EBI

HPV	1 6	1 8	3 1	3 3	3 5	3 9	4 5	5 1	5 2	5 6	5 8	5 9	6 8	7 0	7 3	8 2	2 6	5 3	6 6	6	1 1	4 0	4 2	4 3	4 4	5 4	5 5	6 1	6 2	6 4	6 7	6 9	7 1	7 2	8 1	8 3	8 4	C P 6 1 0 8	I S 0 3 9	7 4
Risk	H	H	H	H	H	H	H	H	H	H	H	H	H	H	H	H	I	I	I	L	L	L	L	L	L	L	L	L	L	L	L	L	L	L	L	L	L	L	L	U
Cervarix	+	+	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
Gardasil	+	+	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	+	+	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
V503	+	+	+	+	-	-	+	-	+	-	+	-	-	-	-	-	-	-	-	+	+	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DigeneHR	+	+	+	+	+	+	+	+	+	+	+	+	+	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DigenePS	+	+	-	-	-	-	+	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CobasHPV	+	+	+	+	+	+	+	+	+	+	+	+	+	-	-	-	-	-	+	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
Digene	+	+	+	+	+	+	+	+	+	+	+	+	+	-	-	-	-	-	-	+	+	-	+	+	+	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HybriBio	+	+	+	+	+	+	+	+	+	+	+	+	+	-	-	-	-	+	+	+	+	-	+	+	+	-	-	-	-	-	-	-	-	-	+	-	-	-	-	-
PapilloCheck	+	+	+	+	+	+	+	+	+	+	+	+	+	+	+	+	-	+	+	+	+	+	+	+	+	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
InnoLiPA	+	+	+	+	+	+	+	+	+	+	+	+	+	+	+	+	+	+	+	+	+	+	-	+	+	+	-	-	-	-	-	+	+	-	-	-	-	-	-	+
LinearArray	+	+	+	+	+	+	+	+	+	+	+	+	+	+	+	+	+	+	+	+	+	+	+	-	-	+	+	+	+	+	+	+	+	+	+	+	+	+	+	-

Legend: 71 (CP 8061), 81 (CP 8304), 82/MM4, 82/IS039, 83 (MM7), 84 (MM8)

References

• Human-papilloma

• 100% of cervical cancers is caused by HPV (human papillomavirus).
• 70% of cervical cancers is caused by HPV types 16 & 18. Which may be prevented by vaccination with Gardasil® or Cervarix®.
• 90% cervical cancers is caused by HPV types 16, 18, 31, 33, 45, 52, and 58. Which may be prevented by vaccination with V503. It may be available by 2013.

References

• Genital warts pictures

Genital warts:

• are usually soft, pink cauliflower-like growths or flesh-coloured bumps on the sex organs
• may also be hard and smooth
• occur alone or in groups
• tend to recur after treatment
• increase the risk of cervical cancer in women.

A person with genital warts can infect others through sexual contact.

Genital warts treatment / HPV treatment

• Physical methods of Genital warts removal
  • Freezing: cryotherapy / cryosurgery with liquid nitrogen.
  • Cutting: Curettage
  • Burning: Electrocautery
• Immune response modifier: Imiquimod

Sexual risk (of HIV/STD/pregnancy), and what you can do before and after exposure.

Note: If the clinic attendance is only for the HIV rapid test, then consultation fees are not added.

References

• HPV vaccine images
• HPV vaccine - Wikipedia, the free encyclopedia
• HPV vaccine: Definition from Answers.com
• HPV vaccine - definition of HPV vaccine in the Medical dictionary - by the Free Online Medical Dictionary, Thesaurus and Encyclopedia.
• WHO | Human papillomavirus and HPV vaccines
• WHO | Human papillomavirus infection and cervical cancer
• Vaccines: VPD-VAC/HPV/main page

Australian boys become first male guinea pigs in global Gardasil genocide
Wed, 27 Feb 2013 06:00:00 +0100 | NaturalNews.com
Nearly one million teenage boys living in Australia are set to be vaccinated with the human papillomavirus (HPV) vaccine Gardasil in the coming months and years, according to new reports. The first country in the world to give an official green light to the vaccine's... (Source: NaturalNews.com)

HMP recommends approval of extension to Cervarix® human papillomavirus vaccine therapeutic indication
Mon, 25 Feb 2013 05:00:00 +0100 | NeLM - News
Source: European Medicines Agency

[Correspondence] Cross protection against HPV might prevent type replacement
Tue, 19 Feb 2013 19:17:44 +0100 | The Lancet Infectious Diseases
Duration of efficacy of the two prophylactic human papillomavirus (HPV) vaccines Cervarix and Gardasil is the most important question for population control of HPV infection, and if the duration exceeds 15 years, the control of cervical cancer. The phase 2 randomised controlled trials were designed to show 5 year efficacy for Gardasil, and 9·4 year efficacy for Cervarix; both phase 3 trials were ended before 4 years. HPV16 and HPV18, the most aggressive oncogenic HPV types, are the main vaccine targets, and have 17% and 11% cumulative incidences of cervical intraepithelial neoplasia grade 3 or greater (CIN3+) over a 10 year period, respectively. (Source: The Lancet Infectious Diseases)

Human Papillomavirus Types Distribution in Eastern Sicilian Females with cervical lesions. A Correlation with Colposcopic and Histological Findings.
Tue, 19 Feb 2013 05:00:00 +0100 | Pathology Oncology Research
Authors: Le Donne M, Giuffrè G, Caruso C, Nicotina PA, Alibrandi A, Scalisi R, Simone A, Chiofalo B, Triolo O

Can clinical tests help monitor human papillomavirus vaccine impact?
Tue, 19 Feb 2013 05:00:00 +0100 | International Journal of Cancer
ABSTRACT

Herd immunity effect of the HPV vaccination program in Australia under different assumptions regarding natural immunity against re-infection.
Tue, 19 Feb 2013 05:00:00 +0100 | Vaccine
Authors: Korostil IA, Peters GW, Law MG, Regan DG

Attitudes Toward HPV Vaccination Among Low-Income and Minority Parents of Sons: A Qualitative Analysis
Fri, 15 Feb 2013 05:00:00 +0100 | Clinical Pediatrics
Conclusions. Low-income and minority parents/guardians were generally receptive toward vaccinating their sons against HPV; racial/ethnic differences emerged regarding school-entry mandates. (Source: Clinical Pediatrics)

Australia launches national scheme to vaccinate boys against HPV
Thu, 14 Feb 2013 05:00:00 +0100 | NeLM - News
Source: BMJ

Validation of Decisional Balance and Self-Efficacy Measures for HPV Vaccination in College Women.
Tue, 12 Feb 2013 05:00:00 +0100 | American Journal of Health Promotion : AJHP
Conclusion. Findings support the internal and external validity of these measures and their use in Transtheoretical Model-tailored interventions. Stage-construct relationships suggest that reducing the Cons of vaccination may be more important for HPV than for behaviors with a true Maintenance stage.

Applying a gender lens on human papillomavirus infection: cervical cancer screening, HPV DNA testing, and HPV vaccination
Fri, 08 Feb 2013 05:00:00 +0100 | International Journal for Equity in Health
Conclusions:

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