Genital Warts Removal | Shim Clinic, Singapore | HIV STD TESTING TREATMENT™

Genital Warts Removal | Shim Clinic, Singapore | HIV STD TESTING TREATMENT™: Genital warts / penile warts / vaginal warts / anal warts / anogenital warts / venereal warts / condyloma / condylomata acuminata / "cauliflower" sex disease symptoms in men/women, screening/diagnosis, testing/check, treatment clinic, Singapore. Private and confidential service. Definitions, references, and latest news.

Description

Table of Contents

• HPV (human papillomavirus)
• HPV Symptoms / Genital warts
• Cervical Cancer
• HPV Screen / HPV Screening / HPV Test / HPV Testing / HPV Check / HPV Checking
  • Digene®
• HPV Treatment / Genital Warts Treatment / Genital Warts Removal
• HPV vaccine / Cervical Cancer Vaccine
  • Gardasil®
  • Cervarix®
  • V503

• Physical methods of Genital warts removal
  • Freezing: cryotherapy / cryosurgery with liquid nitrogen.
  • Cutting: Curettage
  • Burning: Electrocautery
• Immune response modifier: Imiquimod

Genital warts: penile warts / vaginal warts / anal warts / anogenital warts / venereal warts / condyloma / condylomata acuminata / "cauliflower" sex disease.

References

• Genital warts pictures

Genital warts:

• are usually soft, pink cauliflower-like growths or flesh-coloured bumps on the sex organs
• may also be hard and smooth
• occur alone or in groups
• tend to recur after treatment
• increase the risk of cervical cancer in women.

A person with genital warts can infect others through sexual contact.

HPV / human papillomavirus. There are nearly 200 known types of HPV. They cause

• 100% of genital warts
• 100% of cervical cancers in females,
• 90% of anal cancers in males & females
• 40% of external genitalia cancers
  • penile cancers in males,
  • vulvar cancers in females,
  • vaginal cancers in females,
• 12% of oropharyngeal cancers (mouth and throat cancers)
• 3% of oral cancers

• HPV types 1 and 2 cause plantar warts
• HPV types 3 and 10 cause flat warts
• HPV types 6 and 11 (preventable with Gardasil® vaccination) cause 90% of genital warts
• HPV types 16 and 18 (preventable with Gardasil® or Cervarix® vaccination) cause 70% of cervical cancers in females
• HPV types 16, 18, 31, 33, 45, 52, and 58 (preventable with V503 vaccination) cause 90% of cervical cancers in females. It may be available by 2013.

• Human_papillomavirus | 2can Support Portal | EBI

HPV	1 6	1 8	3 1	3 3	3 5	3 9	4 5	5 1	5 2	5 6	5 8	5 9	6 8	7 0	7 3	8 2	2 6	5 3	6 6	6	1 1	4 0	4 2	4 3	4 4	5 4	5 5	6 1	6 2	6 4	6 7	6 9	7 1	7 2	8 1	8 3	8 4	C P 6 1 0 8	I S 0 3 9	7 4
Risk	H	H	H	H	H	H	H	H	H	H	H	H	H	H	H	H	I	I	I	L	L	L	L	L	L	L	L	L	L	L	L	L	L	L	L	L	L	L	L	U
Cervarix	+	+	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
Gardasil	+	+	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	+	+	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
V503	+	+	+	+	-	-	+	-	+	-	+	-	-	-	-	-	-	-	-	+	+	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DigeneHR	+	+	+	+	+	+	+	+	+	+	+	+	+	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DigenePS	+	+	-	-	-	-	+	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CobasHPV	+	+	+	+	+	+	+	+	+	+	+	+	+	-	-	-	-	-	+	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
Digene	+	+	+	+	+	+	+	+	+	+	+	+	+	-	-	-	-	-	-	+	+	-	+	+	+	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HybriBio	+	+	+	+	+	+	+	+	+	+	+	+	+	-	-	-	-	+	+	+	+	-	+	+	+	-	-	-	-	-	-	-	-	-	+	-	-	-	-	-
PapilloCheck	+	+	+	+	+	+	+	+	+	+	+	+	+	+	+	+	-	+	+	+	+	+	+	+	+	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
InnoLiPA	+	+	+	+	+	+	+	+	+	+	+	+	+	+	+	+	+	+	+	+	+	+	-	+	+	+	-	-	-	-	-	+	+	-	-	-	-	-	-	+
LinearArray	+	+	+	+	+	+	+	+	+	+	+	+	+	+	+	+	+	+	+	+	+	+	+	-	-	+	+	+	+	+	+	+	+	+	+	+	+	+	+	-

Legend: 71 (CP 8061), 81 (CP 8304), 82/MM4, 82/IS039, 83 (MM7), 84 (MM8)

References

• Human-papilloma

• 100% of cervical cancers is caused by HPV (human papillomavirus).
• 70% of cervical cancers is caused by HPV types 16 & 18. Which may be prevented by vaccination with Gardasil® or Cervarix®.
• 90% cervical cancers is caused by HPV types 16, 18, 31, 33, 45, 52, and 58. Which may be prevented by vaccination with V503. It may be available by 2013.

• Gardasil® [HPV (Human Papillomavirus) Quadrivalent (Types 6, 11, 16, and 18) Vaccine, Recombinant]
• Cervarix® [HPV (Human Papillomavirus) Bivalent (Types 16 and 18) Vaccine, Recombinant]
• V503 [HPV (Human Papillomavirus) Nonavalent (Types 6, 11, 16, 18, 31, 33, 45, 52, and 58) Vaccine, Recombinant]

• PROFESSIONAL O&G GUIDELINES ON HPV VACCINATION IN SINGAPORE

• 2006 June 8th - US FDA approves use in females aged 9 to 26 years
• 2006 - Singapore HSA approval
• 2008 September 12th - US FDA approves use to prevent vulvar and vaginal cancer
• 2009 October 16th - US FDA approves use to prevent genital warts in males aged 9 to 26 years
• 2010 December 22nd - US FDA approves use to prevent anal cancer in males and females aged 9 to 26 years
• 2010 December 22nd - Singapore HSA approves use to prevent genital warts in males aged 9 to 26 years
• 2011 April 5th - US FDA approves use in women 27 through 45 years of age
• 2011 December 20th Singapore HSA approves use to prevent anal cancer in males and females aged 9 to 26 years

• Gardasil.com
• Gardasil® @ US FDA

• 2007 - Singapore HSA approval
• 2009 October 16th - US FDA approves use in females aged 10 to 25 years
• 2011 July 19th - US FDA approves use in females as young as 9 years of age
• 2011 August 3rd - Singapore HSA approves use for the prevention of persistent infection, premalignant cervical lesions and cervical cancer

• Cervarix.com
• Cervarix® @ US FDA

• 2007 October 12th - Broad Spectrum HPV (Human Papillomavirus) Vaccine Study in 16-to 26-Year-Old Women (V503-001)
• 2009 July 21st - A Study of V503 in Preadolescents and Adolescents (V503-002)
• 2010 May 11th - The Phase III trial is ongoing and Merck anticipates filing a Biologics License Application (BLA) in 2012
• 2010 July - Merck is recruiting for Phase III clinical trials of a nine-valent vaccine

HPV test for men/women.

• Digene® High-Risk HPV DNA Test
  • QIAGEN - digene HC2 High-Risk HPV DNA Test - For detection of human papillomavirus infections using Hybrid Capture 2 technology
  • Detects 13 high-risk HPV types: 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, and 68.
  • Unable to differentiate which types are positive.
  • Cost is SG$200/=
• Digene® HPV DNA Test
  • QIAGEN - digene HC2 HPV DNA Test - For detection of human papillomavirus infections
  • Detects 13 high-risk HPV types: 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, and 68. And 5 low-risk types: 6, 11, 42, 43, and 44.
  • Unable to differentiate which types are positive.
  • Not available in Singapore. Unlikely to be available in the future.
• Digene® HPV Genotyping PS Test
  • QIAGEN - Researchers Say Identification of Women with HPV Types 16, 18 and 45 Could Improve Early Intervention to Stop Cervical Cancer
  • Specifically identifies the presence of types 16, 18 and 45.
  • If the High-Risk HPV DNA Test is positive, then the Genotyping PS Test is done free of charge.
• Hybribio®
  • HPV GenoArray Test Kit
  • Detects 15 high-risk HPV types: 16, 18, 31, 33, 35, 39, 45, 51, 52, 53, 56, 58, 59, 66, and 68. And 6 low-risk HPV types: 6, 11, 42, 43, 44, CP8304
  • Able to differentiate which types are positive.
  • May be available in Singapore soon.
• Cobas® HPV Test
  • Cobas® HPV Test
  • Detects 14 high-risk HPV types: 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 66, and 68
  • The test specifically identifies (types) HPV 16 and HPV 18, while concurrently detecting the rest of the high risk types (31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 66, and 68)
  • Cost is SG$200/=
• LINEAR ARRAY® HPV Genotyping Test
  • LINEAR ARRAY® HPV Genotyping Test
  • Identifies 37 high-risk HPV genotypes 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 66, 68, 73 (MM9), 82 (MM4) low-risk HPV genotypes 6, 11, 26, 40, 42, 53, 54, 55, 61, 62, 64, 67, 69, 70, 71, 72, 81, 83 (MM7), 84 (MM8), IS39, and CP6108
• INNO-LiPA HPV Genotyping Extra
  • INNO-LiPA HPV Genotyping Extra
  • Identifies 15 high-risk HPV genotypes (16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 68, 73, 82) 3 probable high-risk HPV genotypes (26, 53, 66) 7 low-risk HPV genotypes (6, 11, 40, 43, 44, 54, 70) and some additional types (69, 71, 74).
• PapilloCheck®
  • PapilloCheck®
  • Identifies 24 hiv-risk HPV types 16 18 31 33 35 39 45 51 52 53 56 58 59 66 68 70 73 82 and low-risk HPV types 6 11 40 42 43 44

Sexual risk (of HIV/STD/pregnancy), and what you can do before and after exposure.

Note: If the clinic attendance is only for the HIV rapid test, then consultation fees are not added.

References

• Genital warts images
• Genital warts - Wikipedia, the free encyclopedia
• Genital warts: Definition from Answers.com
• Genital warts - definition of Genital warts in the Medical dictionary - by the Free Online Medical Dictionary, Thesaurus and Encyclopedia.

Methylenetetrahydrofolate reductase (MTHFR) polymorphisms and promoter methylation in cervical oncogenic lesions and cancer
Thu, 28 Feb 2013 05:00:00 +0100 | Journal of Cellular and Molecular Medicine
Abstract

Australian boys become first male guinea pigs in global Gardasil genocide
Wed, 27 Feb 2013 06:00:00 +0100 | NaturalNews.com
Nearly one million teenage boys living in Australia are set to be vaccinated with the human papillomavirus (HPV) vaccine Gardasil in the coming months and years, according to new reports. The first country in the world to give an official green light to the vaccine's... (Source: NaturalNews.com)

Comparison of HPV DNA testing in cervical exfoliated cells and tissue biopsies among HIV‐positive women in Kenya
Wed, 27 Feb 2013 05:00:00 +0100 | International Journal of Cancer
In conclusion, testing HPV on biopsies instead of cells results in decreased detection but not elimination of multiple infections in HIV‐positive women. The proportion of CIN2/3 attributable to HPV16 and/or 18 among HIV‐positive women, which already appeared to be lower than that in HIV‐negative, would then further decrease. The meaning of HPV detection in cells and random biopsy from HIV‐positive women with no cervical abnormalities remains unclear. © 2013 Wiley Periodicals, Inc. (Source: International Journal of Cancer)

Survey of human papillomavirus types and their vertical transmission in pregnant women
Wed, 27 Feb 2013 05:00:00 +0100 | BMC Infectious Diseases
Background:

Human papillomavirus and oral disease – emerging evidence: a review
Wed, 27 Feb 2013 05:00:00 +0100 | Australian Dental Journal
(Source: Australian Dental Journal)

Effect of glacial acetic acid treatment of cervical ThinPrep specimens on HPV DNA detection with the cobas 4800 HPV test
Wed, 27 Feb 2013 05:00:00 +0100 | Cytopathology
ConclusionsGlacial acetic acid (GAA) treatment of cervical ThinPrep specimens does not have significant adverse affects on HPV detection with the cobas 4800 HPV Test. (Source: Cytopathology)

Study Documents Head And Neck Cancer Molecular Tumor Subtypes
Tue, 26 Feb 2013 08:00:00 +0100 | Health News from Medical News Today
Head and neck squamous cell carcinoma (HNSCC) is the seventh most common form of cancer in the United States, but other than an association with the human papillomavirus, no validated molecular profile of the disease has been established. By analyzing data from DNA microarrays, a UNC-led team has completed a study that confirms the presence of four molecular classes of the disease and extends previous results by suggesting that there may be an underlying connection between the molecular classes and observed genomic events, some of which affect known cancer genes... (Source: Health News from Medical News Today)

HMP recommends approval of extension to Cervarix® human papillomavirus vaccine therapeutic indication
Mon, 25 Feb 2013 05:00:00 +0100 | NeLM - News
Source: European Medicines Agency

Cervical cytokines and clearance of incident human papillomavirus infection: Hawaii hpv cohort study
Fri, 22 Feb 2013 05:00:00 +0100 | International Journal of Cancer
Abstract

The estimated direct medical cost of selected sexually transmitted infections in the United States, 2008.
Wed, 20 Feb 2013 06:20:07 +0100 | Herpes
CONCLUSIONS: Sexually transmitted infections continue to impose a substantial cost burden on the payers of medical care in the United States. The burden of STIs would be even greater in the absence of STI prevention and control efforts.

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