Cialis® | Shim Clinic, MEN'S CLINIC SINGAPORE™

Cialis® | Shim Clinic, MEN'S CLINIC SINGAPORE™: Male impotence, sexual/erectile dysfunction (ED) symptoms, treatment, drugs/medication clinic, Singapore. Private and confidential service. Definitions, references, and latest news.

Description

Table of Contents

• Erectile Dysfunction (ED) (Sexual Dysfunction / Impotence)
• Erectile Dysfunction Treatment (Impotence Treatment)

• Sildenafil (Viagra®)
• Vardenafil (Levitra®)
• Tadalafil (Cialis®)

Erectile dysfunction may be assessed with the international index of erectile function (IIEF-5) a.k.a. sexual health inventory for men (SHIM), and an erectile dysfunction diagnosis made:

The IIEF-5 questionnaire^a

Over the past six months:
1	How do you rate your confidence that you could get and keep an erection?	Very low	Low	Moderate	High	Very high
		1	2	3	4	5
2	When you had erections with sexual stimulation, how often were your erections hard enough for penetration?	Almost never/never	A few times (much less than half the time)	Sometimes (about half the time)	Most times (much more than half the time)	Almost always/always
		1	2	3	4	5
3	During sexual intercourse, how often were you able to maintain your erection after you had penetrated (entered) your partner?	Almost never/never	A few times (much less than half the time)	Sometimes (about half the time)	Most times (much more than half the time)	Almost always/always
		1	2	3	4	5
4	During sexual intercourse, how difficult was it to maintain your erection to completion of intercourse?	Extremely difficult	Very difficult	Difficult	Slightly difficult	Not difficult
		1	2	3	4	5
5	When you attempted sexual intercourse, how often was it satisfactory for you?	Almost never/never	A few times (much less than half the time)	Sometimes (about half the time)	Most times (much more than half the time)	Almost always/always
		1	2	3	4	5

^aThe IIEF-5 score is the sum of the ordinal responses to the five items; thus, the score can range from 5 to 25.
ED severity: severe (5-7), moderate (8-11), mild to moderate (12-16), mild (17-21), and no ED (22-25)

Men's health issues:

• Erectile dysfunction (ED)
• Premature ejaculation (PE)
• Andropause
• Androgenic alopecia
• STD (Sexually transmitted disease)

• Cialis - Wikipedia, the free encyclopedia
• Cialis: Definition from Answers.com
• Cialis - definition of Cialis in the Medical dictionary - by the Free Online Medical Dictionary, Thesaurus and Encyclopedia.
• RC Rosen, JC Cappelleri, MD Smith, J Lipsky and BM Pena. Development and evaluation of an abridged, 5-item version of the International Index of Erectile Function (IIEF-5) as a diagnostic tool for erectile dysfunction International Journal of Impotence Research (1999) 11, 319-326

Inhibitory effects of phosphodiesterase 5 inhibitor, ---------, on mechanosensitive bladder afferent nerve activities of the rat, and on acrolein‐induced hyperactivity of these nerves
Wed, 16 May 2012 14:16:43 +0100 | BJU International
CONCLUSION• Our study shows, using selective unifibre potential measurement, that systemic administration of --------- reduces mechanosensitive afferent activities of both Aδ‐ and C‐fibres elicited by bladder distension in the rat, and also that --------- has an inhibitory effect on the increased activities of both fibres induced by intravesical acrolein instillation. (Source: BJU International)

Adenoviral short hairpin RNA therapy targeting phosphodiesterase 5a relieves cardiac remodeling and dysfunction following myocardial infarction
Tue, 15 May 2012 04:00:00 +0100 | AJP: Heart and Circulatory Physiology
We previously showed that treatment with ---------, a long-acting phosphodiesterase-5a (PDE5a) inhibitor, effectively prevented adverse left ventricular (LV) remodeling of the infarcted heart. We hypothesized that short-hairpin RNA (shRNA) therapy targeting PDE5a would simulate the effects of pharmacological intervention for treatment of postinfarction LV remodeling and dysfunction. Experimental model of myocardial infarction was developed in female mice by permanent ligation of left coronary artery. Immediately after that, an adenoviral vector encoding for shRNA sequence targeting PDE5a (Ad-shPDE5a) was injected intramyocardially, which specifically inhibited PDE5a in the heart. Four weeks later, Ad-shPDE5a treated mice showed significant mitigation of the left ventricle (LV) dilatation a...

PDE5 inhibitors, ---------- and ----------, reverse multidrug resistance by inhibiting the efflux function of MRP7 (ABCC10) transporter
Fri, 11 May 2012 04:00:00 +0100 | Cancer Science
SummaryPhosphodiesterase type 5 (PDE5) inhibitors are widely used in the treatment of male erectile dysfunction and in improving the breathing efficiency in pulmonary hypertension. Recently, several groups have evaluated the ability of PDE5 inhibitors for their anticancer activities. Previously, we have shown that ----------, ---------- and --------- could reverse P‐glycoprotein (P‐gp, ABCB1)‐mediated multidrug resistance (MDR). In the present study, we determined whether these PDE5 inhibitors have the potential to reverse multidrug resistance protein 7 (MRP7, ABCC10)‐mediated MDR. We found that ---------- and ---------- dose‐dependently enhanced the sensitivity of MRP7‐transfected HEK293 cells to paclitaxel, docetaxel and vinblastine, while --------- had only minimal effect. A...

Intrapulmonary Shear Stress Enhancement: A New Therapeutic Approach in Pulmonary Arterial Hypertension
Sun, 06 May 2012 06:25:14 +0100 | Pediatric Cardiology
Conclusion  Induced with an appropriate device, intrapulmonary shear stress–mediated endothelial function enhancement provides a more effective nearly physiological therapy for PAH. Content Type Journal ArticleCategory Original ArticlePages 1-11DOI 10.1007/s00246-012-0322-8Authors Sayed Nour, Laboratory of Biosurgical Research (Alain Carpentier Foundation), Pompidou Hospital, University Paris Descartes, 75015 Paris, FranceGang Dai, Key Laboratory on Assisted Circulation, Division of Cardiology, Ministry of Health of China, The First Affiliated Hospital of Sun Yat-sen University, 58 Zhongshan Rd II, 510080 Guangzhou, ChinaDaniel Carbognani, Laboratory of Biosurgical Research (Alain Carpentier Foundation), Pompidou Hospital, University Paris Descartes, 75015 Paris, Fr...

Monthly News Round Up - April 2012
Mon, 30 Apr 2012 23:04:24 +0100 | Drugs.com - Pharma News
Stendra: Another Option for Erectile Dysfunction is Approved Joining the ranks of ------ (silenafil), ------ (---------), and ------- (----------), another phosphodiesterase type 5 (PDE5) inhibitor for erectile dysfunction (ED) by the brand name... (Source: Drugs.com - Pharma News)

Analysis of the therapeutic effect of --------- on male ED after transurethral resection of prostate
Thu, 19 Apr 2012 04:00:00 +0100 | International Journal of Impotence Research
Authors: H Yu, H Wu & D Rao (Source: International Journal of Impotence Research)

The effects of long-term administration of --------- on STZ-induced diabetic rats with erectile dysfunction via a local antioxidative mechanism.
Mon, 16 Apr 2012 04:00:00 +0100 | Asian Journal of Andrology
Authors: Chen Y, Li XX, Lin HC, Qiu XF, Gao J, Dai YT, Wang R Abstract Type 5 phosphodiesterase inhibitors (PDE5Is) are well known being effective via the nitric oxide and cyclic guanosine monophosphate (NO-cGMP) pathway and are widely used in the treatment of diabetic erectile dysfunction (ED). However, it is unclear whether other pathways may be involved in the treatment of diabetic ED with PDE5Is. The purpose of this study was to clarify the role of antioxidants in diabetic ED treatment through the long-term administration of PDE5Is. Three groups of Sprague-Dawley rats were utilized: Group N, the normal control; Group D, streptozotocin (STZ)-induced diabetic rats as a control; and Group D+T, STZ-induced diabetic rats who received oral administration of --------- for 8 weeks. Ere...

---------/----------: Central serous chorioretinopathy (first report with ----------): 2 case reports
Sun, 08 Apr 2012 15:14:59 +0100 | Reactions
(Source: Reactions)

---------: First report of aortic dissection: case report
Fri, 06 Apr 2012 23:47:25 +0100 | Reactions
(Source: Reactions)

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