Candida Albicans | Shim Clinic, STD CLINIC SINGAPORE™

Candida Albicans | Shim Clinic, STD CLINIC SINGAPORE™: Candidiasis/thrush, fungal/yeast/Candida infection symptoms in men/women, screening/diagnosis, testing/check, treatment clinic, Singapore. Private and confidential service. Definitions, references, and latest news.

Description

Candidiasis/candidosis/moniliasis/oidiomycosis or penile/vaginal/oral thrush is a fungal infection (mycosis) / yeast infection of any of the Candida species, of which Candida albicans is the most common. It is usually treated with Clotrimazole or Tioconazole pessaries in females, or Fluconazole capsules orally.

References

• Candida albicans - Wikipedia, the free encyclopedia
• Candida albicans: Definition from Answers.com
• Candida albicans - definition of Candida albicans in the Medical dictionary - by the Free Online Medical Dictionary, Thesaurus and Encyclopedia.
• Guidelines for the Management of Sexually Transmitted Infections: 3. TREATMENT OF SPECIFIC INFECTIONS: 3.11. Candidiasis
• Disease Listing: Candidiasis General Information | CDC DFBMD

A key structural domain of the Candida albicans Mdr1 protein
Wed, 16 May 2012 04:00:00 +0100 | BJ Cell
A major multidrug transporter, MDR1, belonging to the Major Facilitator Superfamily (MFS) invariably contributes to an increased efflux of commonly used azoles and thus corroborates their direct involvement in multidrug resistance (MDR) in Candida albicans. The MDR1 protein with two transmembrane domains, each comprising six transmembrane helices, is interconnected with extracellular loops and intracellular loops (ICLs). The introduction of deletions and insertions through mutagenesis was used to address the role of the largest inter-domain ICL3 of the Mdr1 protein. Most of the progressive deletants, when overexpressed, eliminated the drug resistance. Notably, restoration of the length of the ICL3 by insertional mutagenesis did not restore the functionality of the protein. Interestingly, m...

Force microscopic and thermodynamic analysis of the adhesion between Pseudomonas aeruginosa and Candida albicans
Wed, 16 May 2012 01:10:45 +0100 | RSC - Soft Matter latest articles
Soft Matter, 2012, Advance ArticleDOI: 10.1039/C2SM25100K, PaperEkaterina S. Ovchinnikova, Bastiaan P. Krom, Henny C. van der Mei, Henk J. BusscherMannoprotein-layers present on hyphae, but absent on yeast, create favorable conditions for strong adhesion forces between P. aeruginosa and C. albicans.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Soft Matter latest articles)

Disruption of the ECM33 Gene in Candida albicans Prevents Biofilm Formation, Engineered Human Oral Mucosa Tissue Damage and Gingival Cell Necrosis/Apoptosis
Tue, 15 May 2012 18:49:14 +0100 | Experimental Diabetes Research
In this study we demonstrated that ΔCaecm33 double mutant showed reduced biofilm formation and causes less damage to gingival mucosa tissues. This was confirmed by the reduced level of necrotic cells and Bax/Bcl2 gene expression as apoptotic markers. In contrast, parental and Caecm33 mutant strains decreased basement membrane protein production (laminin 5 and type IV collagen). We thus propose that ECM33 gene/protein represents a novel target for the prevention and treatment of infections caused by Candida. (Source: Experimental Diabetes Research)

Candidal mediastinitis successfully treated using vacuum-assisted closure following open-heart surgery
Tue, 15 May 2012 04:00:00 +0100 | Interactive CardioVascular and Thoracic Surgery
Deep sternal wound infections (DSWIs) are an uncommon but serious complication after open-heart surgery. The reported incidence of DSWIs due to Candida albicans is 0.4%, but these infections have an extremely high mortality of 56%. We herein report a rare case of a 79-year old woman who suffered from Candidal DSWI after repeated open-heart surgeries. We treated her with negative pressure wound therapy (NPWT). This is the rare case report that provides evidence that NPWT is a safe and suitable technique for the management of Candidal DSWIs. (Source: Interactive CardioVascular and Thoracic Surgery)

Host Carbon Sources Modulate Cell Wall Architecture, Drug Resistance and Virulence in a Fungal Pathogen
Tue, 15 May 2012 04:00:00 +0100 | Cellular Microbiology
SummaryThe survival of all microbes depends upon their ability to respond to environmental challenges. To establish infection, pathogens such as Candida albicans must mount effective stress responses to counter host defenses whilst adapting to dynamic changes in nutrient status within host niches. Studies of C. albicans stress adaptation have generally been performed on glucose‐grown cells, leaving the effects of alternative carbon sources upon stress resistance largely unexplored. We have shown that growth on alternative carbon sources, such as lactate, strongly influence the resistance of C. albicans to antifungal drugs, osmotic and cell wall stresses. Similar trends were observed in clinical isolates and other pathogenic Candida species. The increased stress resistance of C. albicans ...

Association between carotid intima‐media thickness, buccodental status, and glycemic control in pediatric type 1 diabetes
Mon, 14 May 2012 04:00:00 +0100 | Pediatric Diabetes
Conclusions:More buccodental conditions and carotid intima‐media thickness increase appeared in the patients with HbA1c level > 8.5%, suggesting onset of atherosclerosis. The correlation between buccodental status and HbA1c values may indicate the connection between inflammatory states of atherosclerosis and type 1 diabetes. (Source: Pediatric Diabetes)

The effect of biomaterials and antifungals on biofilm formation by Candida species: a review
Sat, 12 May 2012 06:23:32 +0100 | European Journal of Clinical Microbiology and Infectious Diseases
Abstract   Candida albicans, C. glabrata, C. parapsilosis, and C. tropicalis are able to form biofilms on virtually any biomaterial implanted in a human host. Biofilms are a primary cause of mortality in immunocompromised and hospitalized patients, as they cause recurrent and invasive candidiasis, which is difficult to eradicate. This is due to the fact that the biofilm cells show high resistance to antifungal treatments and the host defense mechanisms, and exhibit an excellent ability to adhere to biomaterials. Elucidation of the mechanisms of antifungal resistance in Candida biofilms is of unquestionable importance; therefore, this review analyzes both the chemical composition of biomaterials used to fabricate the medical devices, as well as the Candida genes and proteins ...

CANDIN (Candida Albicans Skin Test Antigen) Injection, Solution [Allermed Laboratories, Inc.]
Fri, 11 May 2012 05:00:00 +0100 | DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST)
Updated Date: May 11, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Synthesis of naringin 6-ricinoleate using immobilized lipase
Fri, 11 May 2012 04:00:00 +0100 | Chemistry Central Journal
Conclusion: Using immobilized lipase from C. antarctica, the best conversion reaction was observed using castor oil containing ricinoleic acid as the acylating agent rather than an isolated fatty acid. (Source: Chemistry Central Journal)

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